Performance of the Khon Kaen Osteoporosis Study (KKOS) score for identifying osteoporosis in men.

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dc.contributor.authorPongchaiyakul, Chatlerten_US
dc.contributor.authorWanothayaroj, Ekgalucken_US
dc.date.accessioned2009-05-27T21:20:35Z
dc.date.available2009-05-27T21:20:35Z
dc.date.issued2007-08-12en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: The present study evaluated the diagnostic performance of Khon Kaen Osteoporosis Study (KKOS) score in identifying osteoporosis in men. MATERIAL AND METHOD: This was a cross-sectional investigation in 230 men aged > or = 50 years. Bone mineral density (BMD) was measured at the femoral neck and lumbar spine by DXA (DPX-IQ densitometer LUNAR Corporation, Madison, Wisconsin, USA). The KKOS score was calculated for each man using his age and weight. Men with KKOS scores < or = -1 and > -1 were classified as "high risk" and "low risk", respectively. RESULTS: The prevalence of osteoporosis in the entire sample was 17% and 7.4% (n = 39, 17) by femoral neck BMD and lumbar spine BMD, respectively. Using the KKOS score, 80 (34.8%) men were classified as "high risk" (KKOS score < or = -1). The proportion of high risk individuals increased with advancing age, ranging from 16.2% in the 50-65 age group to 64.8% in the > 65 age group. Using BMD from DXA as a gold standard, the overall sensitivity and specificity of KKOS in identifying osteoporosis was 72.5% and 73.2%, respectively. However; the sensitivity was higher at the lumbar spine (94.1% vs. 71.8%) than the femoral neck, while the specificity was comparable. The PPV of KKOS was 36%; and was lower at the lumbar spine (20%) compared to the femoral neck (35%). In the present study, men were classified "high risk" from KKOS, the risk (odds ratio; OR) of osteoporosis at the femoral neck and/or lumbar spine was 7.19 (95% CI: 3.34-15.44). However, the risk of osteoporosis was higher in the younger age (50-65 yr) group (OR: 10.29, 95% CI: 3.31-31.94) compared with the older age (> 65 yr) group (OR: 3.65, 95% CI: 1.12-11.91). CONCLUSION: KKOS scoring system based on age and body weight, is a simple tool for clinicians to make a decision to further DXA testing for identifying osteoporosis in Thai men. This tool had a high sensitivity and specificity, but modest PPV.en_US
dc.description.affiliationDivision of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. pchatl@kku.ac.then_US
dc.identifier.citationPongchaiyakul C, Wanothayaroj E. Performance of the Khon Kaen Osteoporosis Study (KKOS) score for identifying osteoporosis in men. Journal of the Medical Association of Thailand. 2007 Aug; 90(8): 1518-23en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/44622
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshBody Weighten_US
dc.subject.meshBone Densityen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOsteoporosis --diagnosisen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshThailanden_US
dc.titlePerformance of the Khon Kaen Osteoporosis Study (KKOS) score for identifying osteoporosis in men.en_US
dc.typeJournal Articleen_US
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