Frequent seizures and polytherapy can impair quality of life in persons with epilepsy.

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dc.contributor.authorThomas, Sanjeev Ven_US
dc.contributor.authorKoshy, Samuelen_US
dc.contributor.authorNair, C R Sudhakaranen_US
dc.contributor.authorSarma, Sankara Pen_US
dc.date.accessioned2005-03-05en_US
dc.date.accessioned2009-06-03T12:52:50Z
dc.date.available2005-03-05en_US
dc.date.available2009-06-03T12:52:50Z
dc.date.issued2005-03-05en_US
dc.description.abstractCONTEXT: Careful evaluation of pharmacotherapy, seizure control and quality of life (QOL) are helpful in improving epilepsy care but such data are relatively meager from developing countries. AIMS: To audit pharmacotherapy, seizure control and QOL in persons with epilepsy and to identify factors associated with impaired QOL. SETTINGS AND DESIGN & MATERIALS AND METHODS: The study was carried out using a cross-sectional design in the setting of a tertiary care epilepsy center in India. Persons with epilepsy with > 12 months follow-up at this Center and aged > 16 years were eligible for enrollment. Persons with other disabilities or pregnancy were excluded. Subjects were interviewed with a standard questionnaire and an adapted version of Quality of Life in Epilepsy - 31 (QOLIE-31). Data pertaining to treatment at the time of referral to this center was extracted from medical records. STATISTICAL ANALYSIS USED: Chi-square test, analysis of variance and multiple regression analysis were carried out for statistical significance. RESULTS: One hundred and twelve patients with epilepsy (59 males, mean age 31.2+/-10.7 years) were included. Forty-seven (42%) persons had Generalized Epilepsy (GE) and 65 persons (58%) had Localization-Related Epilepsy (LRE). At entry 24 persons (21.4%) were not on treatment and 59 persons (64.8%) had frequent seizures. At last follow-up 64 persons (57.1%) were seizure-free, 83 persons (74.1%) were on monotherapy and 29 were (25.9%) on polytherapy. Cost of drug at entry was INR 2276 (monotherapy) and INR 3629 (polytherapy) (45 INR = 1 USD). At the time of last follow-up, it was 1898 and 4929 respectively. QOLIE-31 Total Score (TQOL) ranged from 22.6 to 94.4 (mean 68.0 +/- 15.8). Multiple regression analysis showed significant correlation between low TQOL score and polytherapy (P=0.002) and occurrence of one or more seizures per month (P=0.001). CONCLUSIONS: Frequent seizures and polytherapy are associated with lower QOL in persons with epilepsy.en_US
dc.description.affiliationDepartment of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India. sanjeev@sctimst.ker.nic.inen_US
dc.identifier.citationThomas SV, Koshy S, Nair CR, Sarma SP. Frequent seizures and polytherapy can impair quality of life in persons with epilepsy. Neurology India. 2005 Mar; 53(1): 46-50en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/121847
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnticonvulsants --adverse effectsen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDrug Costsen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshEpilepsy, Generalized --drug therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshQuality of Lifeen_US
dc.titleFrequent seizures and polytherapy can impair quality of life in persons with epilepsy.en_US
dc.typeJournal Articleen_US
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