Post-COVID multisystem inflammatory syndrome in adults: a study from a tertiary care hospital in south India

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dc.contributor.authorDas, Bikramen_US
dc.contributor.authorJoshi, Divyaen_US
dc.contributor.authorVineeth, V.K.en_US
dc.contributor.authorNaveen, A. S.en_US
dc.contributor.authorGopalakrishnan, Ramen_US
dc.contributor.authorRamasubramanian, V.en_US
dc.contributor.authorDevi, V.R. Yamunaen_US
dc.contributor.authorNambi, P. Senthuren_US
dc.date.accessioned2023-08-19T04:52:29Z
dc.date.available2023-08-19T04:52:29Z
dc.date.issued2022-11
dc.description.abstractBackground & objectives: There are limited data from India on the post-COVID multisystem inflammatory syndrome in adults (MIS-A). The objective of the present study was to evaluate the clinical profile of patients with MIS-A admitted to a tertiary care centre in southern India. Methods: This single-centre retrospective study was conducted from November 2020 to July 2021, and included patients aged >18 yr admitted to the hospital as per the inclusion and exclusion criteria. Results: Nine patients (5 male, mean age 40±13 yr) met the criteria for MIS-A. Five patients had proven COVID-19 infection or contact history 36.8±11.8 days back. All patients were positive for SARS-CoV-2 IgG antibody, negative for COVID-19 PCR, and had negative blood, urine and sputum cultures. All patients had fever and gastrointestinal (GI) symptoms, and five patients had left ventricular dysfunction. All patients had neutrophilic leucocytosis at presentation and elevated biomarkers such as C-reactive protein serum procalcitonin, D-dimer and ferritin. The majority of the patients (7/9 i.e. 77.78%) were treated with intravenous hydrocortisone (50-100 mg q6h-q8h). Six patients recovered completely whereas three patients expired. Interpretation & conclusions: Fever and GI symptoms were the most common presentation of MIS-A. Elevated serum procalcitonin may not be useful in differentiating bacterial sepsis from MIS-A. Most patients responded to corticosteroids.en_US
dc.identifier.affiliationsDepartment of Infectious Diseases, Apollo Hospitals, Chennai, Tamil Nadu, Indiaen_US
dc.identifier.citationDas Bikram, Joshi Divya, Vineeth V.K., Naveen A. S., Gopalakrishnan Ram, Ramasubramanian V., Devi V.R. Yamuna, Nambi P. Senthur. Post-COVID multisystem inflammatory syndrome in adults: a study from a tertiary care hospital in south India. Indian Journal of Medical Research. 2022 Nov; 156(4-5): 669-673en_US
dc.identifier.issn0971-5916
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223694
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber4-5en_US
dc.relation.volume156en_US
dc.source.urihttps://doi.org/10.4103/ijmr.ijmr_70_22en_US
dc.subjectMultiorgan involvement in adulten_US
dc.subjectmultisystem inflammatory syndrome in adultsen_US
dc.subjectpost COVIDen_US
dc.subjectprocalcitoninen_US
dc.titlePost-COVID multisystem inflammatory syndrome in adults: a study from a tertiary care hospital in south Indiaen_US
dc.typeJournal Articleen_US
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