Is endothelial-nitric-oxide-synthase-derived nitric oxide involved in cardiac hypoxia/reoxygenation-related damage.

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dc.contributor.authorRus, A
dc.contributor.authorPeinado, MA
dc.contributor.authorBlanco, S
dc.contributor.authorMoral, ML del
dc.date.accessioned2015-08-07T06:20:41Z
dc.date.available2015-08-07T06:20:41Z
dc.date.issued2011-03
dc.description.abstractNitric oxide (NO) has been reported to act both as a destructive and a protective agent in the pathogenesis of the injuries that occur during hypoxia/reoxygenation (H/R). It has been suggested that this dual role of NO depends directly on the isoform of NO synthase (NOS) involved. In this work, we investigate the role that NO derived from endothelial NOS (eNOS) plays in cardiac H/R-induced injury.Wistar rats were submitted to H/R (hypoxia for 30 min; reoxygenation of 0 h, 12 h and 5 days), with or without prior treatment using the selective eNOS inhibitor L-NIO (20 mg/kg). Lipid peroxidation, apoptosis and protein nitration, as well as NO production (NOx), were analysed. The results showed that L-NIO administration lowered NOx levels in all the experimental groups. However, no change was found in the lipid peroxidation level, the percentage of apoptotic cells or nitrated protein expression, implying that eNOS-derived NO may not be involved in the injuries occurring during H/R in the heart. We conclude that LNIO would not be useful in alleviating the adverse effects of cardiac H/R.en_US
dc.identifier.citationRus A, Peinado MA, Blanco S, Moral ML del. Is endothelial-nitric-oxide-synthase-derived nitric oxide involved in cardiac hypoxia/reoxygenation-related damage. Journal of Biosciences. 2011 Mar; 36(1): 69-78.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/161513
dc.language.isoenen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/mar2011/69.pdfen_US
dc.subjectApoptosisen_US
dc.subjectendothelial nitric oxide synthaseen_US
dc.subjecthypoxiaen_US
dc.subjectL-NIOen_US
dc.subjectnitric oxideen_US
dc.subjectreoxygenationen_US
dc.titleIs endothelial-nitric-oxide-synthase-derived nitric oxide involved in cardiac hypoxia/reoxygenation-related damage.en_US
dc.typeArticleen_US
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