A clinicopathological study of gestational trophoblastic diseases in a tertiary healthcare centre

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dc.contributor.authorKakadiya, HHen_US
dc.contributor.authorNishal, AJen_US
dc.contributor.authorDesai, PMen_US
dc.contributor.authorViradiya, RH.en_US
dc.date.accessioned2025-08-13T11:44:22Z
dc.date.available2025-08-13T11:44:22Z
dc.date.issued2025-07
dc.description.abstractBackground: Gestational trophoblastic diseases are marked by abnormal proliferation of various trophoblastic cells during placentation. It includes hydatidiform mole, invasive mole, choriocarcinoma, placental site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT). GTNs are among the rare human tumours that can be cured even in the presence of widespread dissemination. Aims of present study was to assess histomorphological features of GTD along with its clinical correlation. Methods: It was an observational cross-sectional study conducted in the Department of Pathology, at tertiary healthcare centre in South Gujarat over a period of 5 years from January 2019 to December 2023. Histological finding of all cases were recorded and clinical correlation done. Results: Out of 50 analysed cases of GTDs, 47 cases (94%) were Hydatiform mole and 3 cases (6%) were choriocarcinoma. The incidence of gestational trophoblastic diseases is found to be 1 in 799 pregnancies. Age ranged from 18-35 years. The most commonly affected age group was 20-25 years with 29 cases (58%). Most cases were presented in the first trimester. Most common clinical presentation was bleeding per vagina in 34 cases (68%) followed by abdominal pain. The majority of GTD cases belonged to 50,000 to <1,00,000 mlU/ml beta-HCG level. Conclusions: Hydatidiform mole is most prevalent gestational trophoblastic disease. Present study signifies the importance of routine histopathological examination of products of conception to rule out microscopic molar changes, since there is an higher incidence of molar pregnancies progressing to choriocarcinoma, a highly metastasizing neoplasm.en_US
dc.identifier.affiliationsDepartment of Pathology, Government Medical College, Surat, Gujarat, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Government Medical College, Surat, Gujarat, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Government Medical College, Surat, Gujarat, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Government Medical College, Surat, Gujarat, Indiaen_US
dc.identifier.citationKakadiya HH, Nishal AJ, Desai PM, Viradiya RH.. A clinicopathological study of gestational trophoblastic diseases in a tertiary healthcare centre . International Journal of Research in Medical Sciences. 2025 Jul; 13(7): 2878-2883en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/254207
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber7en_US
dc.relation.volume13en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20252021en_US
dc.subjectBeta-hCGen_US
dc.subjectChoriocarcinomaen_US
dc.subjectGestational trophoblastic diseaseen_US
dc.subjectHydatidiform moleen_US
dc.titleA clinicopathological study of gestational trophoblastic diseases in a tertiary healthcare centreen_US
dc.typeJournal Articleen_US
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