Transition of drug susceptibilities of Vibrio cholerae O1 in Lao People's Democratic Republic.

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dc.contributor.authorPhantouamath, Ben_US
dc.contributor.authorSithivong, Nen_US
dc.contributor.authorSisavath, Len_US
dc.contributor.authorMunnalath, Ken_US
dc.contributor.authorKhampheng, Cen_US
dc.contributor.authorInsisiengmay, Sen_US
dc.contributor.authorHiga, Nen_US
dc.contributor.authorKakinohana, Sen_US
dc.contributor.authorIwanaga, Men_US
dc.date.accessioned2009-05-27T14:40:47Z
dc.date.available2009-05-27T14:40:47Z
dc.date.issued2001-03-04en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe changes of drug susceptibilities of Vibrio cholerae O1 isolated during the past 7 years (1993-1999) in Lao PDR were investigated. The most noteworthy finding was the appearance of polymyxin B sensitive El Tor vibrios. Until 1996, the susceptibilities were almost as expected and cholera disappeared in 1997. When a cholera outbreak resurfaced in 1998, the susceptibilities of isolated V. cholerae O1 against tetracycline, sulfamethoxazol-trimethoprim, chloramphenicol and polymyxin B were quite different from those of previously isolated organisms. Minimum inhibitory concentrations (MICs) of tetracycline and chloramphenicol against the isolates in 1998 were about 16 times higher than those against the previous isolates, and the MICs of sulfamethoxazol-trimethoprim were about 256 times higher than those against the previous isolates, (trimethoprim 32 microg/ml: sulfamethoxazol 608 microg/ml). Eleven percent of the isolates (11/99) were as sensitive to polymyxin B as the classic cholera vibrios (MIC < 2 microg/ml). In 1999, the susceptibility pattern was almost the same as that in 1998 except for polymyxin B to which 58% of the isolates (21/36) became sensitive.en_US
dc.description.affiliationCenter for Laboratory and Epidemiology, Ministry of Health, Vientiane, Lao PDR.en_US
dc.identifier.citationPhantouamath B, Sithivong N, Sisavath L, Munnalath K, Khampheng C, Insisiengmay S, Higa N, Kakinohana S, Iwanaga M. Transition of drug susceptibilities of Vibrio cholerae O1 in Lao People's Democratic Republic. The Southeast Asian Journal of Tropical Medicine and Public Health. 2001 Mar; 32(1): 95-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/30787
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2001_32_1/15-2644.pdfen_US
dc.subject.meshAnti-Bacterial Agents --pharmacologyen_US
dc.subject.meshCholera --drug therapyen_US
dc.subject.meshDisease Outbreaksen_US
dc.subject.meshDrug Resistance, Microbialen_US
dc.subject.meshHumansen_US
dc.subject.meshLaos --epidemiologyen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshVibrio cholerae --drug effectsen_US
dc.titleTransition of drug susceptibilities of Vibrio cholerae O1 in Lao People's Democratic Republic.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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