Hepatitis A Virus-related Pediatric Liver Disease Burden and its Significance in the Indian Subcontinent

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dc.contributor.authorSood, Vikranten_US
dc.contributor.authorLal, Bikrant Biharien_US
dc.contributor.authorGupta, Ektaen_US
dc.contributor.authorKhanna, Rajeeven_US
dc.contributor.authorSiloliya, Manish Ken_US
dc.contributor.authorAlam, Seemaen_US
dc.date.accessioned2020-04-23T07:44:25Z
dc.date.available2020-04-23T07:44:25Z
dc.date.issued2019-09
dc.description.abstractObjectives: To study the Hepatitis A virus (HAV) infection-related pediatric liver diseaseburden. Methods: Hospitalrecords of 431 children (age <18 y) diagnosed to be sufferingfrom acute HAV infection during 2011 to 2018 were extracted and analyzed. Additionally, aseroprevalence study was done on 2599 participants (696 children and 1903 adults).Results: HAV infection accounted for about half (48.6% of acute hepatitis and 46.5% (92/198) of acute liver failure cases) of all acute onset icteric illness, with significant morbidity andmortality. As per seroprevalence data, 16.2% of children between 10-18 years of age, and10.3% of adults aged 18-30 years remained susceptible to HAV infection. Conclusion: HAVinfection is the major contributor the overall pediatric liver disease burden. A significantproportion of subjects remain susceptible to HAV infection even after 10 years of age.Population-based studies are required to further delineate the epidemiology of HAV infectionin India for deciding introduction of HAV vaccine in the national immunization schedule.en_US
dc.identifier.affiliationsDepartments of Pediatric Hepatology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi,Indiaen_US
dc.identifier.affiliationsClinical Virology, Institute of Liver and Biliary Sciences, Vasant Kunj, New Delhi,India.en_US
dc.identifier.citationSood Vikrant, Lal Bikrant Bihari, Gupta Ekta, Khanna Rajeev, Siloliya Manish K, Alam Seema. Hepatitis A Virus-related Pediatric Liver Disease Burden and its Significance in the Indian Subcontinent. Indian Pediatrics. 2019 Sep; 56(9): 741-744en_US
dc.identifier.issn0974-7559
dc.identifier.issn0019-6061
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/199382
dc.languageenen_US
dc.publisherIndian Academy of Pediatricsen_US
dc.relation.issuenumber9en_US
dc.relation.volume56en_US
dc.source.urihttps://www.indianpediatrics.net/sep2019/741.pdfen_US
dc.subjectAcute viral hepatitisen_US
dc.subjectHepatitis A infectionen_US
dc.subjectSeroprevalence rateen_US
dc.subjectVaccinationen_US
dc.titleHepatitis A Virus-related Pediatric Liver Disease Burden and its Significance in the Indian Subcontinenten_US
dc.typeJournal Articleen_US
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