Benefit of electrocardiography during front-line combination paclitaxel and carboplatin chemotherapy for epithelial ovarian cancer.

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dc.contributor.authorKietpeerakool, Chumnanen_US
dc.contributor.authorTiyayon, Jitimaen_US
dc.contributor.authorSuprasert, Prapapornen_US
dc.contributor.authorKanjanavanit, Rungsriten_US
dc.contributor.authorSrisomboon, Jatupolen_US
dc.date.accessioned2009-05-27T18:13:30Z
dc.date.available2009-05-27T18:13:30Z
dc.date.issued2006-11-09en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To evaluate the patterns of electrocardiography (ECG), cardiac risk factors and its clinical consequence in women with epithelial ovarian cancer (EOC) who received paclitaxel and carboplatin (PC) as front line chemotherapy. MATERIAL AND METHOD: The medical records and electrocardiographic data of women with EOC who received paclitaxel (175 mg/min2) and carboplatin (AUC=5) every 3 weeks at Chiang Mai University Hospital between January 2000 and December 2004 were reviewed for cardiac risk factors and clinical consequence. RESULTS: Among 79 women receiving PC for EOC, 43 (54.4%) had cardiac risk factors. Seventy (88.6%) women had normal ECG, the remaining nine had sinus tachycardia (5), bundle branch block (2), mild T inversion (1), and Wolff-Parkinson-White syndrome (1) before the first course of chemotherapy. Among 70 women with normal initial ECG 8 (11.4%) had sinus tachycardia, one (1.4%) had early depolarization, two (2.9%) had sinus bradycardia and three (4.3%) had sinus arrhythmia in subsequent ECG All these cardiac disturbances were asymptomatic and needed no intervention, indicating grade I toxicity. The odds ratio of developing abnormal ECG in women with cardiac risk factor was 1.24 (95% CI = 0.33 to 4.64, p = 0.77). Among nine patients with abnormal ECG before the first course of PC, six (66.7%) had subsequent abnormal ECG but all were asymptomatic and no worsening of abnormal ECG pattern was noted. CONCLUSION: Although paclitaxel and carboplatin chemotherapy could induce abnormal ECG in women with either normal or abnormal prior ECG, its consequence was of no clinical significance. Therefore, the benefit of ECG before each treatment course was theoretically limited.en_US
dc.description.affiliationDepartment of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. kiet_ji@hotmail.comen_US
dc.identifier.citationKietpeerakool C, Tiyayon J, Suprasert P, Kanjanavanit R, Srisomboon J. Benefit of electrocardiography during front-line combination paclitaxel and carboplatin chemotherapy for epithelial ovarian cancer. Journal of the Medical Association of Thailand. 2006 Nov; 89(11): 1805-10en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/38712
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAgeden_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols --adverse effectsen_US
dc.subject.meshCarboplatin --administration & dosageen_US
dc.subject.meshElectrocardiographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Diseases --chemically induceden_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOvarian Neoplasms --drug therapyen_US
dc.subject.meshPaclitaxel --administration & dosageen_US
dc.subject.meshRisk Factorsen_US
dc.titleBenefit of electrocardiography during front-line combination paclitaxel and carboplatin chemotherapy for epithelial ovarian cancer.en_US
dc.typeJournal Articleen_US
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