Preliminary evaluation of indigenous 90Y-labelled microspheres for therapy of hepatocellular carcinoma.

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dc.contributor.authorSubramanian, Suresh
dc.contributor.authorPandey, Usha
dc.contributor.authorChaudhari, Pradip
dc.contributor.authorTyagi, Monica
dc.contributor.authorGupta, Sanjay
dc.contributor.authorSingh, Geetanjali
dc.contributor.authorDash, Ashutosh
dc.contributor.authorSamuel, Grace
dc.contributor.authorVenkatesh, Meera
dc.date.accessioned2016-11-24T06:03:16Z
dc.date.available2016-11-24T06:03:16Z
dc.date.issued2016-05
dc.description.abstractBackground & objectives: Yttrium-90 (90Y)-based radioembolization has been employed to treat hepatocellular carcinoma (HCC) as commercial radioactive glass and polymeric resin microspheres. However, in India and other Asian countries, these preparations must be imported and are expensive, validating the need for development of indigenous alternatives. This work was aimed to develop an economically and logistically favourable indigenous alternative to imported radioembolizing agents for HCC therapy. Methods: The preparation of 90Y-labelled Biorex 70 microspheres was optimized and in vitro stability was assessed. Hepatic tumour model was generated in Sprague-Dawley rats by orthotopic implantation of N1S1 rat HCC cell line. In vivo localization and retention of the 90Y-labelled Biorex 70 microspheres was assessed for seven days, and impact on N1S1 tumour growth was studied by histological examination and biochemical assays. Results: Under optimal conditions, >95% 90Y-labelling yield of Biorex70 resin microspheres was obtained, and these showed excellent in vitro stability of labelling (>95%) at seven days. In animal studies, 90Y-labelled Biorex 70 microspheres were retained (87.72±1.56% retained in liver at 7 days). Rats administered with 90Y-labelled Biorex 70 microspheres exhibited lower tumour to liver weight ratio, reduced serum alpha-foetoprotein level and greater damage to tumour tissue as compared to controls. Interpretation & conclusions: 90Y-labelled Biorex 70 microspheres showed stable retention in the liver and therapeutic effect on tumour tissue, indicating the potential for further study towards clinical use.en_US
dc.identifier.citationSubramanian Suresh, Pandey Usha, Chaudhari Pradip, Tyagi Monica, Gupta Sanjay, Singh Geetanjali, Dash Ashutosh, Samuel Grace, Venkatesh Meera. Preliminary evaluation of indigenous 90Y-labelled microspheres for therapy of hepatocellular carcinoma. Indian Journal of Medical Research. 2015 May; 143(Suppl_1): 74-81.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/178792
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080932/en_US
dc.subjectBiorex 70 resinen_US
dc.subjecthepatocellular carcinomaen_US
dc.subjectradioembolizationen_US
dc.subjecttherapeutic radiopharmaceuticalsen_US
dc.subjectyttrium-90en_US
dc.titlePreliminary evaluation of indigenous 90Y-labelled microspheres for therapy of hepatocellular carcinoma.en_US
dc.typeArticleen_US
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