Hepatocarcinogenic potential of genotype 5 of hepatitis C virus.

Simple item page
dc.contributor.authorKedda, M Aen_US
dc.contributor.authorKew, M Cen_US
dc.contributor.authorCoppin, Aen_US
dc.date.accessioned1997-10-05en_US
dc.date.accessioned2009-06-04T03:55:42Z
dc.date.available1997-10-05en_US
dc.date.available2009-06-04T03:55:42Z
dc.date.issued1997-10-05en_US
dc.description.abstractEvidence is emerging that hepatitis C virus genotypes have different carcinogenic potentials. The hepatocarcinogenicity of genotype 5, the predominant subtype in hepatitis C virus isolates in South Africa, is not known. We have compared the prevalence of genotype 5 of hepatitis C virus in 44 southern African blacks with hepatitis C virus-related hepatocellular carcinoma with that in a comparable group of patients with hepatitis C virus-induced chronic liver disease (cirrhosis or chronic hepatitis) in the absence of cancer. Hepatitis C virus serotypes 1 to 6 were identified by measuring type-specific antibodies to NS4-derived peptide antigens. Serotype 5 was present in 48% (21/44) of the patients with hepatocellular carcinoma and 37% (15/41) of those with liver disease in the absence of hepatocellular carcinoma, an insignificant difference. Although the numbers of the other genotypes were small, the differences in the prevalence rates of these serotypes between the two groups of patients were also not significant. We conclude that genotype 5 of the hepatitis C virus is neither more nor less carcinogenic than other genotypes found in isolates in South Africa.en_US
dc.description.affiliationDepartment of Medicine, University of the Witwatersrand, Johannesburg, South Africa.en_US
dc.identifier.citationKedda MA, Kew MC, Coppin A. Hepatocarcinogenic potential of genotype 5 of hepatitis C virus. Tropical Gastroenterology. 1997 Oct-Dec; 18(4): 153-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/124592
dc.language.isoengen_US
dc.source.urihttps://www.tropicalgastro.comen_US
dc.subject.meshCarcinoma, Hepatocellular --epidemiologyen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHepacivirus --classificationen_US
dc.subject.meshHepatitis C, Chronic --epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasms --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrevalenceen_US
dc.subject.meshSeroepidemiologic Studiesen_US
dc.subject.meshSouth Africa --epidemiologyen_US
dc.titleHepatocarcinogenic potential of genotype 5 of hepatitis C virus.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Tropical Gastroenterology