Efficacy and safety of combinations of H1 antihistamines in the treatment of urticaria: A scoping review

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dc.contributor.authorLuo, Men_US
dc.contributor.authorShen, Ken_US
dc.contributor.authorDong, Xen_US
dc.contributor.authorZhang, Wen_US
dc.contributor.authorTang, F.en_US
dc.date.accessioned2025-06-18T11:42:23Z
dc.date.available2025-06-18T11:42:23Z
dc.date.issued2025-02
dc.description.abstractThe efficacy and safety of combining H1 antihistamines (AHs) for treating urticaria are currently unclear. This scoping review aims to provide a comprehensive overview of the evidence regarding the efficacy and safety of H1 AH combinations in the management of urticaria up to May 2023. The search encompassed databases such as PubMed, Web of Science, the Cochrane Central Register of Controlled Trials, and the China Biological Medicine Database. The inclusion criteria comprised randomised controlled trials (RCTs), non-randomised trials (NRTs), case reports, and case series focusing on urticaria treatment. Initially screening 12,887 studies, this review ultimately selected 109 studies involving 11,435 patients. These studies documented 43 different combination treatments across 11 types of urticaria. In comparison to monotherapy, combination therapy exhibited superior efficacy in 94 studies that reported treatment efficacy. Regarding adverse drug reactions (ADRs), 67 studies disclosed ADR incidences, with combination therapy showing lower ADR rates in 32 studies. Additionally, 7 studies reported similar ADR rates between combination therapy and monotherapy with AHs. Common ADRs included symptoms such as drowsiness, nausea, fatigue, dry mouth, dizziness, and headache, while less frequent side effects encompassed hypotension, otitis media, polyuria, rhinorrhoea, abnormal liver function, and rash. ADR rates ranged from 0% to 21% in the treatment group, and from 0.5% to 75% in the control group. Importantly, patients generally tolerated these ADRs well, with symptoms resolving upon discontinuation of treatment. The study’s findings suggest that combining AHs leads to enhanced efficacy and reduced safety risks compared to monotherapy in the context of urticaria treatment. These results advocate for considering combination therapy as a viable option in clinical practice, especially for chronic urticaria cases. Nonetheless, caution is advised, and close monitoring for potential ADRs is crucial during treatment.en_US
dc.identifier.affiliationsDepartment of Clinical Pharmacy, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, Chinaen_US
dc.identifier.affiliationsDepartment of Clinical Pharmacy, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, Chinaen_US
dc.identifier.affiliationsDepartment of Clinical Pharmacy, Key Laboratory of Basic Pharmacology of Guizhou Province and School of Pharmacy, Zunyi Medical University, Zunyi, Chinaen_US
dc.identifier.affiliationsDepartment of Clinical Pharmacy, Affiliated Hospital of Zunyi Medical University, Zunyi, Chinaen_US
dc.identifier.affiliationsKey Laboratory of Clinical Pharmacy in Zunyi City, Zunyi Medical University, Zunyi, Chinaen_US
dc.identifier.citationLuo M, Shen K, Dong X, Zhang W, Tang F.. Efficacy and safety of combinations of H1 antihistamines in the treatment of urticaria: A scoping review. Indian Journal of Dermatology, Venereology and Leprology. 2025 Feb; 91(1): 49-58en_US
dc.identifier.issn0378-6323
dc.identifier.issn0973-3922
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249402
dc.languageenen_US
dc.publisherScientific Scholar on behalf of Indian Association of Dermatologists, Venereologists & Leprologists (IADVL), India.en_US
dc.relation.issuenumber1en_US
dc.relation.volume91en_US
dc.source.urihttps://dx.doi.org/10.25259/IJDVL_1218_2023en_US
dc.subjectAdverse drug reactionsen_US
dc.subjectcombination drug therapyen_US
dc.subjectefficacyen_US
dc.subjectH1 antihistaminesen_US
dc.subjecturticaria.en_US
dc.titleEfficacy and safety of combinations of H1 antihistamines in the treatment of urticaria: A scoping reviewen_US
dc.typeJournal Articleen_US
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