Universal Leukoreduction Decreases the Incidence of Febrile Nonhemolytic Transfusion Reactions to Cellular Blood Components: A 5 Year Study.

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dc.contributor.authorSharma, Dharmesh Chandra
dc.contributor.authorRai, Sunita
dc.contributor.authorGupta, Shruti
dc.contributor.authorJain, Bharat
dc.date.accessioned2014-08-04T11:33:55Z
dc.date.available2014-08-04T11:33:55Z
dc.date.issued2014-11
dc.description.abstractBackground: Febrile nonhemolytic transfusion reactions (FNHTRs) are common complications associated with allogenic transfusion and it is caused by the leucocytes and cytokines released by leucocytes during storage of blood/ blood components. These reactions are generally not life threatening, but they are expensive in their management, evaluation, and associated blood-product wastage. 1st log prestorage universal leukoreduction (ULR) i.e. removal of Buffy coat is a useful and effective procedure in developing countries to control FNHTRs significantly. Aims and Objects: To know the efficacy of pre-storage 1st log universal leuckoreduction in controlling febrile nonhemolytic transfusion reactions (FNHTRs). Place and Duration of Study: Study was carried out at Blood Bank, Department of Pathology, G. R. Medical College, Gwalior from January 2009 to December 2013 (5years). Materials and Methods: Study was divided into control group (Year: 2009) and study group (Years: 2010-13). 14,292 recipients in control group and 45,064 in study group were transfused with non-leukoreduced and prestorage 1st log leukoreduced blood/ blood components respectively. Usefulness of prestorage 1st log ULR over non-leukoreduced blood/ blood components was observed, compared and discussed. Result: In the control group 610 (4.26%) out of 14,292 (p=0.0003) and in study group 381(0.84%) out of 45,064 (p=0.0003) recipients were reported to have FNHTRs. The comparative study showed significant reduction in FNHTRs from 4.26% to 0.84% (↓ 3.42%) (p=0.000001). Conclusion: 1st log Universal Leukoreduction (ULR) is a better option over Selective Leukoreduction (SLR) to prevent FNHTRs and it also helps the transfusion services of under-resourced developing countries in many ways.en_US
dc.identifier.citationSharma Dharmesh Chandra, Rai Sunita, Gupta Shruti, Jain Bharat. Universal Leukoreduction Decreases the Incidence of Febrile Nonhemolytic Transfusion Reactions to Cellular Blood Components: A 5 Year Study. International Blood Research & Reviews. 2014 Nov-dec:2(6): 279-288.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/153506
dc.language.isoenen_US
dc.source.urihttps://www.sciencedomain.org/abstract.php?iid=576&id=28&aid=5222en_US
dc.subjectBlood transfusionen_US
dc.subjectuniversal leukoreductionen_US
dc.subjectselective leukoreductionen_US
dc.subjectfebrile non hemolytic transfusion reactionen_US
dc.titleUniversal Leukoreduction Decreases the Incidence of Febrile Nonhemolytic Transfusion Reactions to Cellular Blood Components: A 5 Year Study.en_US
dc.typeArticleen_US
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