Association of vascular endothelial growth factor single nucleotide polymorphisms on the prognosis of breast cancer patients.

Simple item page
dc.contributor.authorRani, J
dc.contributor.authorRahul, B
dc.contributor.authorRamesh, G
dc.contributor.authorKrishnamoorthy, L
dc.contributor.authorShilpa, C
dc.contributor.authorRamaswamy, G
dc.contributor.authorDeshmane, V
dc.date.accessioned2016-02-11T11:39:24Z
dc.date.available2016-02-11T11:39:24Z
dc.date.issued2014-10
dc.description.abstractBACKGROUND: Vascular endothelial growth factor (VEGF), a major mediator of vascular permeability and angiogenesis, may play a pivotal role in mediating the development and progression of breast cancer. In the present study, we examined the genetic variations of the VEGF gene to assess its possible relation to breast cancer. MATERIALS AND METHODS: A total of 200 patients with histologically confirmed cases of breast cancer and 200 healthy women were genotyped for VEGF single nucleotide polymorphisms (405G > C and −1154G > A) by polymerase chain reaction‑restriction fragment length polymorphism analysis. Pre‑operative plasma VEGF levels were determined by enzyme‑linked immunosorbent assay in 200 women with breast cancer and in 200 normal female controls. RESULTS: The genotype frequencies of the +405G > C, −1154G > A polymorphisms did not show a significant deviation from the Hardy‑Weinberg expectation. The minor allele frequencies of the +405G > C and −1154G > A polymorphisms among cases and controls were 33.5% (C allele), 31.5% (A allele) and 35% (C allele), 34.5% (A allele) respectively. +405GG and −1154GG genotypes were associated with higher levels of VEGF among breast cancer cases and controls. Increased plasma VEGF levels were significantly associated with, clinical stage of the disease (P = 0.035). CONCLUSION: Although none of the polymorphisms were significantly associated with breast cancer, some of the VEGF genotypes may influence tumor growth through an altered expression of VEGF and tumor angiogenesis.en_US
dc.identifier.citationRani J, Rahul B, Ramesh G, Krishnamoorthy L, Shilpa C, Ramaswamy G, Deshmane V. Association of vascular endothelial growth factor single nucleotide polymorphisms on the prognosis of breast cancer patients. Indian Journal of Cancer. 2014 Oct-Dec; 51(4): 512-517.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/172494
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2014;volume=51;issue=4;spage=512;epage=517;aulast=Ranien_US
dc.subjectBreast canceren_US
dc.subjectplasma vascular endothelial growth factoren_US
dc.subjectvascular endothelial growth factor polymorphismen_US
dc.titleAssociation of vascular endothelial growth factor single nucleotide polymorphisms on the prognosis of breast cancer patients.en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijc2014v51n4p512.pdf
Size:
520.54 KB
Format:
Adobe Portable Document Format
Description:
Original article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Cancer