Sub Acute Toxicity Study of Mixed Fungal Culture Filtrates Isolated from Maize Stalks of Shivamogga District in Rats
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Date
2024-12
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Ms. M. B. Mondal, Ph.D.
Abstract
Aim: To assess effects of the toxicity caused by consuming the fungal contaminated fodder by the cattle in the field conditions. Study Design: Study was conducted in 3 groups of Wistar Albino rats. Place and Duration of Study: Department of Veterinary Pharmacology and Toxicology and Department of Veterinary Pathology, Veterinary College Shivamogga, Karnataka, between August 2024 to October 2024. Methodology: A repeated-dose 28-days oral sub acute toxicity study was performed with three groups (n=6) of Wistar Albino rats. The group I (control) received oral gavage of potato dextrose broth @ dose of 2 mL/100g, where as groups II and III received mixed fungal culture filtrate of Aspergillus flavus and Aspergillus niger at the doses of 1 and 2 mL/100 g respectively. Results: Treated groups (group II and III) showed increase in serological parameters (Aspartate Transaminase, Alanine transaminase, Creatinine, Blood urea nitrogen) and decrease in hematological parameters (PCV, Hb, TLC, TEC). Conclusion: The findings of the present study inferred that the fungal culture filtrates of fungus isolated from contaminated maize stalk caused toxicity in rats, which was attributed for the presence of a toxic principle components in the fungal culture filtrates.
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Keywords
Aspergillus flavus, Aspergillus niger, toxicity study, rats
Citation
Uppar M, Tikare VP, Shridhar NB, Sunilchandra U, Ravikumar P, Nagaraja K.. Sub Acute Toxicity Study of Mixed Fungal Culture Filtrates Isolated from Maize Stalks of Shivamogga District in Rats . Microbiology Research Journal International. 2024 Dec; 34(12): 244-254