A study of proliferative activity, angiogenesis and nuclear grading in renal cell carcinoma.

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dc.contributor.authorBhattacharyya, N Ken_US
dc.contributor.authorChatterjee, Uen_US
dc.contributor.authorSarkar, Sen_US
dc.contributor.authorKundu, A Ken_US
dc.date.accessioned2008-01-18en_US
dc.date.accessioned2009-05-29T13:16:15Z
dc.date.available2008-01-18en_US
dc.date.available2009-05-29T13:16:15Z
dc.date.issued2008-01-18en_US
dc.description.abstractTo evaluate the role of proliferative marker, proliferating cell nuclear antigen (PCNA) and microvessel density (MVD) as prognostic markers in renal cell carcinoma (RCC) and to see their relationship with the clinical stage and nuclear grades, we studied 30 cases of RCC for nuclear grading (Fuhrman's nuclear grade), MVD (using anti CD-34 antibody), and PCNA labeling index (using anti-PCNA antibody) over a period of 2.5 years. Staging was assessed by peroperative and radiologic findings. The area of highest MVD within the tumor was selected for microvessel count (MVC) per high-power field (0.1885 mm 2 area). PCNA labeling index was determined by counting percentage of positively stained tumor cell nuclei. PCNA labeling index above 60% was taken as high PCNA index and up to 60% was considered low. There was significant positive correlation between PCNA labeling index with both nuclear grade and clinical stage using Spearman's correlation coefficient. No association was noted between MVC with PCNA, nuclear grade, and clinical stages. Evaluation of proliferative status of RCC is a useful adjunct as a prognostic parameter as it is seen to correlate well with both clinical stage and nuclear grade. In our study, MVD was not seen to correlate with either of these.en_US
dc.description.affiliationDepartment of Pathology, Medical College, Kolkata, India. drnbhattacharya@yahoo.co.inen_US
dc.identifier.citationBhattacharyya NK, Chatterjee U, Sarkar S, Kundu AK. A study of proliferative activity, angiogenesis and nuclear grading in renal cell carcinoma. Indian Journal of Pathology & Microbiology. 2008 Jan-Mar; 51(1): 17-21en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/75472
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntigens, CD34 --analysisen_US
dc.subject.meshCarcinoma, Renal Cell --diagnosisen_US
dc.subject.meshCell Nucleus --pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney --radiographyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeovascularization, Pathologicen_US
dc.subject.meshPrognosisen_US
dc.subject.meshProliferating Cell Nuclear Antigen --analysisen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshStatistics as Topicen_US
dc.subject.meshTumor Markers, Biologicalen_US
dc.titleA study of proliferative activity, angiogenesis and nuclear grading in renal cell carcinoma.en_US
dc.typeJournal Articleen_US
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