C-reactive protein in patients with Guillain Barré syndrome.
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Date
2014-01
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Abstract
Context: C-reactive protein (CRP) is an acute phase reactant, widely used as
a biomarker for various infectious and infl ammatory conditions. Guillain-Barré
syndrome (GBS) is an acute, autoimmune, polyradiculoneuropathy, triggered by
infectious agents such as Campylobacter jejuni. GBS is generally precipitated 1-3
weeks following C. jejuni infection which suggests a humoral immunopathogenic
mechanism. Aims: Basal CRP levels were estimated in sera of patients with
GBS and compared with adequate controls. Settings & Design: The study
population was divided into 4 groups: (i) GBS group included 45 newly diagnosed
GBS patients; (ii) Neurological control (NC) group comprised of 59 patients
with non-paralytic neurological symptoms/disorders; (iii) Non-neurological
controls (NNC) comprised of 43 patients having no neurological symptoms and
(iv) Healthy controls (HC) comprised of 101 healthy subjects. Materials and
Methods: CRP was evaluated using slide latex agglutination test (LAT) and
enzyme linked immunosorbent assay (ELISA). Statistical Analysis: Statistical
analysis was done by the Chi-square test. Results: CRP by LAT was positive
in 24.4% GBS group, 34% NC group and 44% NNC group. The range of titer
in CRP positive samples in the three patient groups (GBS, NC, NNC) was at
concentration of 0.6 mg/dl to 19.2 mg/dl. Similar results were also obtained by
ELISA in the patient groups. None of the HC subjects was positive for detectable
levels of CRP. High basal level of CRP was detected in patients with GBS.
Conclusion: Autoimmune conditions like GBS can stimulate the production
of a high level of infl ammation resulting in an increase in the CRP production.
Description
Keywords
C-reactive protein, ELISA, Guillain Barre’ syndrome, slide agglutination
Citation
Vaishnavi Chetana, Kapoor Prashant, Behura Chitra, Singh Shrawan Kumar, Prabhakar Sudesh. C-reactive protein in patients with Guillain Barré syndrome. Indian Journal of Pathology & Microbiology. 2014 Jan-Mar 57 (1): 51-54.