Mechanism of lead induced effects on human spermatozoa after occupational exposure.

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dc.contributor.authorNaha, Nen_US
dc.contributor.authorManna, Ben_US
dc.date.accessioned2009-05-28T04:13:25Z
dc.date.available2009-05-28T04:13:25Z
dc.date.issued2007-01-08en_US
dc.descriptionKathmandu University Medical Journal.en_US
dc.description.abstractOBJECTIVES: Occupational lead exposure caused several types of male reproductive impairments in different working populations. In the present study we examined the paint factory workers of active reproductive age and compared the data with the non-occupationally exposed desk job holders taken as control from Bangalore, India. MATERIALS AND METHODS: In the above perspective, sperm cell morphology, morphometery and motile activity were assessed. Routine seminal biochemistry, cell cycle phase analysis of sperm head DNA, estimation of serum reproductive hormones and metal levels in blood and semen were also taken into account. RESULT: Low sperm velocity, ATPase activity, gross and forward progressive motility with high stationary motile spermatozoa revealed lowering of cellular activity after lead exposure (p<0.001), which was supported by high seminal plasma fructose level (p<0.001). Lowering of seminal plasma total protein with concomitant rise in free amino acid level was prevalent as the exposure increased (p<0.001), suggesting disturbance in cellular nutritional support essential for cellular motility. Prolonged liquefaction time, reduced semen volume and viscosity as well as altered seminal plasma protein, fructose and cholesterol level among the workers indicated dysfunction of accessory sex glands viz. prostate and seminal vesicle after occupational lead exposure (p<0.001). Deterioration of sperm count, structural abnormality of spermatozoa and sperm head DNA hyploidy was also associated with high blood and semen lead levels in the paint factory workers (p<0.001) without interfering serum FSH, LH and testosterone level (non-significant at p<0.05). CONCLUSION: Therefore, the present study suggested that at the present exposure level lead might cross blood-testis-barrier and increased its value in semen of the occupationally exposed paint factory workers in Bangalore, India, thereby producing detrimental effects on semen quality and sperm characteristics.en_US
dc.description.affiliationThe Oxford College of Physiotherapy, Bangalore, India. niv_639@yahoo.co.inen_US
dc.identifier.citationNaha N, Manna B. Mechanism of lead induced effects on human spermatozoa after occupational exposure. Kathmandu University Medical Journal. 2007 Jan-Mar; 5(1): 85-94en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/46622
dc.language.isoengen_US
dc.source.urihttps://www.kumj.com.npen_US
dc.source.urihttps://kumj.com.np/ftp/issue/17/85-94-Mechanism-of-lead-induced-effects-on-human-spermatozoa.pdfen_US
dc.subject.meshAdulten_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshLead --toxicityen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOccupational Exposure --adverse effectsen_US
dc.subject.meshPaint --toxicityen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshSemen --drug effectsen_US
dc.subject.meshSperm Counten_US
dc.subject.meshSperm Motility --drug effectsen_US
dc.subject.meshSpermatozoa --drug effectsen_US
dc.subject.meshTestosterone --blooden_US
dc.titleMechanism of lead induced effects on human spermatozoa after occupational exposure.en_US
dc.typeJournal Articleen_US
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