Formulation And Characterization Of Ondansetron Hydrochloride Matrix Tablets For Sustained Drug Delivery

Simple item page
dc.contributor.authorGupta, P.en_US
dc.contributor.authorSethi, V. A.en_US
dc.contributor.authorSiddiqui, A. W.en_US
dc.contributor.authorTyagi, L. K.en_US
dc.date.accessioned2020-10-16T07:50:01Z
dc.date.available2020-10-16T07:50:01Z
dc.date.issued2019-07
dc.description.abstractThe objective of proposed work was to develop Ondansetron Hydrochloride (OND HCl) sustained release matrix tablets for the better treatment of vomiting for extended period of time. Sustained release matrix tablet is the drug delivery system that is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. The matrix tablets of OND HCl were prepared by direct compression method using varying ratio of hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose. The bends of tablets were evaluated for bulk and tapped density, % compressibility index and angle of repose and powder of all formulations blend exhibited that low interparticle friction and excellent flow characteristics. The prepared matrix tablets were then assessed for different physical tests like consistency of weight, thickness, hardness, friability, drug content and in vitro drug release. Each batch of the OND HCl matrix tablets were of good quality as to hardness, thickness, friability and % medicament content. The in vitro drug release study was done for 2 hours by utilizing paddle technique in 0.1N HCl (pH 1.2) as dissolution media and 6 hours using phosphate buffer (pH 6.8) as dissolution media. The drug release study showed that all formulation FMT-1, FMT-2, FMT-3, FMT-4, FMT-5 and FMT-6 were provide the drug release on sustained manner up to 8 hrs. Amongst the developed matrix tablets formulations, FMT-2 containing ethyl cellulose (100 mg) was optimized as best because FMT-2 show highest drug release profile and promoting the sustained release of drug, which could potentially improve the patient compliance.en_US
dc.identifier.affiliationsLloyd Institute of Management and Technology, Greater Noida-201 306, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsLloyd Institute of Management and Technology, Greater Noida-201 306, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsLloyd Institute of Management and Technology, Greater Noida-201 306, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsLloyd Institute of Management and Technology, Greater Noida-201 306, Uttar Pradesh, Indiaen_US
dc.identifier.citationGupta P., Sethi V. A., Siddiqui A. W., Tyagi L. K.. Formulation And Characterization Of Ondansetron Hydrochloride Matrix Tablets For Sustained Drug Delivery. International Journal of Pharmaceutical Sciences and Drug Research. 2019 Jul; 11(4): 147-151en_US
dc.identifier.issn0975-248X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/206239
dc.languageenen_US
dc.publisherMRI Publication Pvt. Ltd.en_US
dc.relation.issuenumber4en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.25004/IJPSDR.2019.110408en_US
dc.subjectOndansetron HClen_US
dc.subjectHPMCen_US
dc.subjectEthyl celluloseen_US
dc.subjectMatrix tabletsen_US
dc.subjectSustained actionen_US
dc.titleFormulation And Characterization Of Ondansetron Hydrochloride Matrix Tablets For Sustained Drug Deliveryen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijpsdr2019v11n4p147.pdf
Size:
637.26 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Pharmaceutical Sciences and Drug Research