Buprenorphine pharmacokinetic parameters during coronary artery bypass graft surgery.

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dc.contributor.authorAmani, Aen_US
dc.contributor.authorJoseph, Ten_US
dc.contributor.authorBalasaraswathi, Ken_US
dc.date.accessioned1997-10-11en_US
dc.date.accessioned2009-06-01T08:12:30Z
dc.date.available1997-10-11en_US
dc.date.available2009-06-01T08:12:30Z
dc.date.issued1997-10-11en_US
dc.description.abstractThe pharmacokinetic parameters of buprenorphine (BN) after a single bolus dose of 10 microg/kg i.v. was investigated in 6 male patients whose age averaged 59+/-9.8 years and body weight of 65.8+/-5.7 kg undergoing coronary artery bypass graft surgery (CABG). The unbound BN plasma concentrations were detected using ultrafiltration and high performance liquid chromatography/electro-chemical detection (HPLC/ECD) method. During cardiopulmonary bypass (CPB) there was a fall in BN plasma concentrations, observations similar to reports on fentanyl, sufentanil and alfentanil. This is probably due to haemodilution, hypothermia and hydrophobic sequestration of drug on to the CPB tubing. After CPB the concentrations rose to values higher than during CPB, though it did not attain pre CPB concentrations. These variations were not statistically significant indicating that plasma levels were adequately stable during CPB. The plasma concentration time curves were biexponential and the pharmacokinetic parameters obtained were : distribution half-life 37.24+/-6.57 min, elimination half-life 482.69+/-79 min, clearance 1221.97+/-209.42 ml/min, and volume of distribution 736.46+/-71.25 L. BN in the dose used follows the pharmacokinetic pattern of other commonly used narcotics during CABG. The mean +/- SEM plasma BN concentration during CPB was 0.51+/-0.03 ng/ml which was adequate for the maintenance of analgesia and anaesthesia, as none of our patients expressed the signs and symptoms of awareness during surgery. Further, unlike the other narcotics muscle rigidity was absent. Thus BN is a safe and good alternative to other narcotics for patients undergoing CABG.en_US
dc.description.affiliationDepartment of Anaesthesiology, M.S.R. Medical College, Bangalore.en_US
dc.identifier.citationAmani A, Joseph T, Balasaraswathi K. Buprenorphine pharmacokinetic parameters during coronary artery bypass graft surgery. Indian Journal of Physiology and Pharmacology. 1997 Oct; 41(4): 361-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108738
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnalgesics, Opioid --blooden_US
dc.subject.meshBuprenorphine --blooden_US
dc.subject.meshCoronary Artery Bypassen_US
dc.subject.meshCoronary Disease --metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleBuprenorphine pharmacokinetic parameters during coronary artery bypass graft surgery.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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