Neoadjuvant chemotherapy before surgery of hepatoblastoma.

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dc.contributor.authorUdupa, K Ven_US
dc.contributor.authorNavadgi, S Men_US
dc.contributor.authorMullerpatan, Pen_US
dc.contributor.authorChhabra, Den_US
dc.contributor.authorShah, R Cen_US
dc.contributor.authorJagannath, Pen_US
dc.date.accessioned2006-08-29en_US
dc.date.accessioned2009-05-30T15:22:07Z
dc.date.available2006-08-29en_US
dc.date.available2009-05-30T15:22:07Z
dc.date.issued2006-08-29en_US
dc.description.abstractThough surgical resection is the main stay of treatment for childhood hepatoblastoma (HB), many are unsuitable for radical surgery at diagnosis due to extensive intrahepatic and/or extra hepatic disease. We report experience in five patients of HB from a single institution (2001-2005) with preoperative Neoadjuvant chemotherapy (NACT) followed by surgery. Three patients received cisplatin, doxorubicin; and two cisplatin / vincristine /5-fluorouracil. All showed more than 50% reduction in tumor size confirmed by CT scan. Hepatic resection R0 was performed in all. There was no chemotherapy related toxicity nor post surgical morbidity or mortality. All are disease free at median follow up of 4 years. NACT produces adequate down staging of the HB with acceptable toxicity. Though cisplatin with doxorubicin produced good results, new protocol with cisplatin, vincristine and 5FU is promising without cardiotoxicity.en_US
dc.description.affiliationDepartment of Surgical Oncology, Lilavati Hospital and Research Centre, Mumbai, India.en_US
dc.identifier.citationUdupa KV, Navadgi SM, Mullerpatan P, Chhabra D, Shah RC, Jagannath P. Neoadjuvant chemotherapy before surgery of hepatoblastoma. Indian Journal of Pediatrics. 2006 Aug; 73(8): 735-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/83554
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols --therapeutic useen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshHepatectomyen_US
dc.subject.meshHepatoblastoma --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshLiver Neoplasms --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshNeoadjuvant Therapyen_US
dc.titleNeoadjuvant chemotherapy before surgery of hepatoblastoma.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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