Brain stem auditory evoked potential response in neonates after recovery from hyperbilirubinemia: A neurophysiological approach to screening neuronal hearing loss

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dc.contributor.authorYadav, RLen_US
dc.contributor.authorYadav, LKen_US
dc.contributor.authorBhusal, Pen_US
dc.contributor.authorTimilsina, Sen_US
dc.contributor.authorSapkota, NKen_US
dc.contributor.authorIslam, MN.en_US
dc.date.accessioned2023-08-09T06:47:45Z
dc.date.available2023-08-09T06:47:45Z
dc.date.issued2022-04
dc.description.abstractObjectives: Neonatal hyperbilirubinemia leads to neurological damages including encephalopathy and hearing loss. This study aimed to screen and evaluate the hearing loss in neonates after recovery from hyperbilirubinemia using the Brainstem evoked response audiometry (BERA) test. Materials and Methods: This cross-sectional comparative study was conducted in Physiology Department at Chitwan Medical College, Nepal. It included 20 age and sex-matched neonates recently recovered from hyperbilirubinemia and 20 normal healthy controls. The external acoustic canals of subjects were checked for any blockage or collapse before BERA testing. The BERA recordings were performed after the neonate’s natural sleep following a standard lab protocol explained by Taylor’s Evoked Potential in Clinical Testing. Results: The BERA wave latencies were delayed with a higher number of case group neonates I (IL-75%, IR-80%), III (IIIL-70%, III R-80%), and V (VL- 80%, VR-85%) than those of controls. The percentage of neonates with delayed interwave latencies was comparable between groups. The neonate’s hearing sensitivity assessed using the grades of hearing impairment by WHO revealed slight (threshold of hearing left ear [THL]-25% and threshold of hearing right ear [THR]-30%) and moderate (THL-40% and THR-35%) grades among cases whereas no impairment (THL-60% and THR-55%) in controls. The hearing thresholds were more in cases. Conclusion: The auditory pathway is highly sensitive to elevated serum bilirubin. BERA detects even a minute degree of hearing damage seen after complete treatment of hyperbilirubinemia. Therefore, BERA is a helpful tool in the early screening of hearing impairment in neonates. This improves prognosis by early management so that the neurosensory systems develop to their full extent and one can enjoy a normal social life.en_US
dc.identifier.affiliationsDepartments of Physiologyen_US
dc.identifier.affiliationsMicrobiolgy, Chitwan Medical College, Bharatpur, Bagmati, Nepal,en_US
dc.identifier.affiliationsDepartment of Physiology, College of Pharmacy, University of Hafr AI Batin, Al Jamiah, Hafar Al Batin, Saudi Arabiaen_US
dc.identifier.citationYadav RL, Yadav LK, Bhusal P, Timilsina S, Sapkota NK, Islam MN.. Brain stem auditory evoked potential response in neonates after recovery from hyperbilirubinemia: A neurophysiological approach to screening neuronal hearing loss. Indian Journal of Medical Sciences. 2022 Apr; 74(1): 27-31en_US
dc.identifier.issn1998-3654
dc.identifier.issn0019-5359
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/222868
dc.languageenen_US
dc.publisherScientific Scholaren_US
dc.relation.issuenumber1en_US
dc.relation.volume74en_US
dc.source.urihttps://doi.org/10.25259/IJMS_342_2021en_US
dc.subjectBrainstem auditory evoked potential testen_US
dc.subjectHearing evaluationen_US
dc.subjectNeonatal hearing lossen_US
dc.subjectNeonatal hyperbilirubinemiaen_US
dc.titleBrain stem auditory evoked potential response in neonates after recovery from hyperbilirubinemia: A neurophysiological approach to screening neuronal hearing lossen_US
dc.typeJournal Articleen_US
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