Efforts in diagnosing early leprosy using serological techniques.
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Date
1997-01
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Abstract
Skin scrapings obtained from the lesions of leprosy patients of all types showed 96%
positivity to the serum antibody competition test using monoclonal antibody (ML04)to 35 kDa
antigen of Mycobacterium leprae. Further, in vitro culture of full thickness skin biopsies from
lepromatous patients were noted to release IgG antibodies to M. leprae with a peak antibody
response at 48 h. The significance of this local antibody response to Μ. leprae in skin has been
discussed for its possible use in diagnosing early leprosy.
Description
Keywords
Leprosy, Mycobacterium leprae 35 kDa antigen, skin scrapings, skin biopsies
Citation
Parkash Om, Beuria M K, Girdhar B K, Katoch K, Sengupta U. Efforts in diagnosing early leprosy using serological techniques. Journal of Biosciences. 1997 Jan; 22(1): 111-116.