Role of protozoa as risk factors for persistent diarrhea.

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dc.contributor.authorBhandari, Nen_US
dc.contributor.authorBahl, Ren_US
dc.contributor.authorDua, Ten_US
dc.contributor.authorKumar, Ren_US
dc.contributor.authorSrivastava, Ren_US
dc.date.accessioned1999-01-08en_US
dc.date.accessioned2009-05-30T13:34:37Z
dc.date.available1999-01-08en_US
dc.date.available2009-05-30T13:34:37Z
dc.date.issued1999-01-08en_US
dc.description.abstractA case control study including 175 children aged 0-36 months suffering from diarrhea of > or = 14 days duration was undertaken to determine whether there is an association between Giardia lamblia, Entamoeba histolytica or Cryptosporidium infection and persistent diarrhea (PD). Subjects were identified by ongoing household surveillance and enrolled as cases. For each case two controls were selected by survey of neighbouring households--a child with acute diarrhea and one without diarrhea. Both the controls were matched with the case for age and nutritional status. Two fresh stool samples were collected from all cases and controls at enrollment and examined for trophozoites of Giardia lamblia, Entamoeba histolytica and Cryptosporidium. Giardia lamblia trophozoites were detected in a significantly higher proportion of PD cases (20.0%) than acute diarrheal and non diarrheal controls (4.6% each, p < 0.0001). There were no significant differences in the proportion of cases and controls who passed E. histolytica trophozoites or cryptosporidium in their stools. There was a consistent trend towards poorer weight gain in PD cases who passed Giardia trophozoites in stool; the differences were statistically significant at days 14 and 21, after enrollment. Giardia lamblia infection is more prevalent in PD cases than in acute diarrhea or non-diarrheal controls. This prevalence is not high enough to warrant routine anti-giardia therapy in patients with PD. However, as giardiasis was observed to have adverse growth impact in PD cases, stool microscopy for detection and subsequent treatment of Giardia lamblia seems to be justified.en_US
dc.description.affiliationICMR Advanced Centre for Diarrheal Disease Research, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationBhandari N, Bahl R, Dua T, Kumar R, Srivastava R. Role of protozoa as risk factors for persistent diarrhea. Indian Journal of Pediatrics. 1999 Jan-Feb; 66(1): 21-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/81824
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCryptosporidium --isolation & purificationen_US
dc.subject.meshDiarrhea, Infantile --parasitologyen_US
dc.subject.meshEntamoeba histolytica --isolation & purificationen_US
dc.subject.meshGiardia lamblia --isolation & purificationen_US
dc.subject.meshGiardiasis --complicationsen_US
dc.subject.meshHealth Surveysen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRisk Factorsen_US
dc.titleRole of protozoa as risk factors for persistent diarrhea.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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