Dizocilpine, ketamine and ethanol reverse NMDA-induced EEG changes and convulsions in rats and mice.

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dc.contributor.authorSharma, A Cen_US
dc.contributor.authorThorat, S Nen_US
dc.contributor.authorNayar, Uen_US
dc.contributor.authorKulkarni, S Ken_US
dc.date.accessioned1991-04-01en_US
dc.date.accessioned2009-06-01T05:47:53Z
dc.date.available1991-04-01en_US
dc.date.available2009-06-01T05:47:53Z
dc.date.issued1991-04-01en_US
dc.description.abstractElectroencephalographic (EEG) activity in neocortex of rats following intracerebroventricular (icv) administration of NMDA (0.25-2 nmol/10 microliters) and its modification by noncompetitive NMDA-receptor antagonists, dizocilpine (MK-801) (0.025-0.1 mg/kg, ip) and ketamine (10-50 mg/kg, ip) was recorded at 0, 0.5, 4, 8 and 24 hr with chronically implanted electrodes. NMDA (0.25 and 1 nmol) showed longer lasting decrease in frequency in cortical neurons while 2 nmol produced convulsions and death. Administration of MK 801 (0.05 mg/kg) and ketamine (50 mg/kg) prior to NMDA offered protection in 40% of animals against NMDA-induced convulsions and blocked NMDA-induced long term influence. However, ketamine and MK 801 showed an increase in percent amplitude and also had long lasting effects per se. In conscious mice, NMDA (0.5-10 nmol/microliters icv) induced dose dependent convulsions. Both MK 801 and ketamine showed potent anticonvulsant effect. Ethanol (0.5-2 g/kg, ip) also offered significant protection against NMDA-induced convulsions. MK 801 (0.1 mg/kg) when administered concurrently with ethanol (0.5 g/kg) exhibited synergistic anticonvulsant effect. The EEG study in rats and effect of NMDA in conscious mice provide a direct evidence for the role of NMDA-receptor system in convulsions and in anticonvulsant action of ethanol.en_US
dc.description.affiliationDepartment of Pharmaceutical Sciences, Panjab University, Chandigarh.en_US
dc.identifier.citationSharma AC, Thorat SN, Nayar U, Kulkarni SK. Dizocilpine, ketamine and ethanol reverse NMDA-induced EEG changes and convulsions in rats and mice. Indian Journal of Physiology and Pharmacology. 1991 Apr; 35(2): 111-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106890
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCerebral Cortex --drug effectsen_US
dc.subject.meshDizocilpine Maleate --pharmacologyen_US
dc.subject.meshElectroencephalography --drug effectsen_US
dc.subject.meshEthanol --pharmacologyen_US
dc.subject.meshKetamine --pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshN-Methylaspartate --antagonists & inhibitorsen_US
dc.subject.meshRatsen_US
dc.subject.meshReceptors, N-Methyl-D-Aspartate --metabolismen_US
dc.subject.meshSeizures --chemically induceden_US
dc.titleDizocilpine, ketamine and ethanol reverse NMDA-induced EEG changes and convulsions in rats and mice.en_US
dc.typeJournal Articleen_US
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