Usage Pattern of Fixed-dose Combinations at ICMR Network of Rational Use of Medicine Centres across India: Recommendations for Policymakers and Prescribers

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dc.contributor.authorRanjalkar, Jayaen_US
dc.contributor.authorJhaj, Ratinderen_US
dc.contributor.authorChandy, Sujith, Jen_US
dc.contributor.authorBright, Heber, Ren_US
dc.contributor.authorChugh, Preeta, Ken_US
dc.contributor.authorTripathi, Chakra Den_US
dc.contributor.authorBadyal, Dinesh Ken_US
dc.contributor.authorBalakrishnan, Sadasivamen_US
dc.contributor.authorMedhi, Bikashen_US
dc.contributor.authorKamat, Sandhya, Ken_US
dc.contributor.authorTripathi, Raakhien_US
dc.contributor.authorDikshit, Hariharen_US
dc.contributor.authorRoy, Sukalyan Sen_US
dc.contributor.authorChatterjee, Suparnaen_US
dc.contributor.authorBhattacharjee, Manjarien_US
dc.contributor.authorTrivedi, Niyatien_US
dc.contributor.authorDesai, Chetnaen_US
dc.contributor.authorGupta, Poojaen_US
dc.contributor.authorRoy, Atanuen_US
dc.contributor.authorRaveendran, Ramasamyen_US
dc.contributor.authorMathaiyan, Jayanthien_US
dc.contributor.authorKaushal, Sandeepen_US
dc.contributor.authorJain, Samritien_US
dc.contributor.authorKaul, Rajnien_US
dc.contributor.authorKshirsagar, Nilima Aen_US
dc.date.accessioned2023-06-17T08:22:21Z
dc.date.available2023-06-17T08:22:21Z
dc.date.issued2023-02
dc.description.abstractAim: Irrational use of medicines is a global problem. In India, one contributing factor is the availability of a large number of fixed-dose combinations (FDCs). To improve rational use and to strengthen policies, it is important to assess the usage patterns and rationality of FDCs. Methods: This study was conducted as part of a 1-year prospective cross-sectional analysis of prescriptions in the outpatient clinics of broad specialities from 13 tertiary care hospitals across India. Five most commonly prescribed FDCs in each center were analyzed. In addition, all the prescribed FDCs were classified as per the Kokate Committee classification and it was noted whether any of the FDCs were irrational or banned as per the reference lists released by regulatory authorities. Results: A total of 4,838 prescriptions were analyzed. Of these, 2,093 (43.3%) prescriptions had at least one FDC. These 2,093 prescriptions had 366 different FDCs. Of the 366 FDCs, 241 were rational; 10 were irrational; 14 required further data generation; and the remaining 96 FDCs could not be categorized into any of the above. Vitamins and minerals/supplements, antibacterial for systemic use, and drugs for gastroesophageal reflux disease (GERD) and peptic ulcer were the most used FDCs. Conclusion: Based on the finding that some prescriptions contained irrational FDCs, it is recommended that a rigorous, regular, and uniform method of evaluation be implemented to approve/ban FDCs and that prescribers be periodically notified about the status of the bans.en_US
dc.identifier.affiliationsSenior Research Officer (former), Department of Pharmacology and Clinical Pharmacology, Christian Medical College, Vellore, Tamil Naduen_US
dc.identifier.affiliationsAdditional Professor, Department of Pharmacology, All India Institute of Medical Sciences, Bhopal, Madhya Pradeshen_US
dc.identifier.affiliationsProfessor and Head, Department of Pharmacology and Clinical Pharmacology, Christian Medical Collegeen_US
dc.identifier.affiliationsLecturer, Department of Pharmacy, Christian Medical College, Vellore, Tamil Naduen_US
dc.identifier.affiliationsAssociate Professoren_US
dc.identifier.affiliationsProfessor and Former Head of the Department, Department of Pharmacology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhien_US
dc.identifier.affiliationsProfessor and Head, Department of Pharmacology, Christian Medical College, Ludhiana, Punjaben_US
dc.identifier.affiliationsProfessor and Head, Department of Pharmacology, All India Institute of Medical Sciences, Bhopal, Madhya Pradeshen_US
dc.identifier.affiliationsProfessor, Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh, Punjaben_US
dc.identifier.affiliationsProfessor and Headen_US
dc.identifier.affiliationsAssociate Professor, Department of Pharmacology and Therapeutics, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtraen_US
dc.identifier.affiliationsProfessor and Headen_US
dc.identifier.affiliationsAssociate Professor, Department of Pharmacology, Indira Gandhi Institute of Medical Science, Patna, Biharen_US
dc.identifier.affiliationsProfessoren_US
dc.identifier.affiliationsPharmacovigilance Associate, Department of Pharmacology,Institute of Postgraduate Medical Education & Research, Kolkata, West Bengalen_US
dc.identifier.affiliationsProfessor and Head,Department of Pharmacology, Medical College Baroda, Vadodaraen_US
dc.identifier.affiliationsProfessor and Head, Department of Pharmacology, B.J. Medical College, Ahmedabad, Gujaraten_US
dc.identifier.affiliationsAdditional Professoren_US
dc.identifier.affiliationsEx-Research Associate, Department of Pharmacology, All India Institute of Medical Sciences, New Delhien_US
dc.identifier.affiliationsProfessor and former Headen_US
dc.identifier.affiliationsProfessor and Head, Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherryen_US
dc.identifier.affiliationsProfessor and Headen_US
dc.identifier.affiliationsResident, Department of Pharmacology, Dayanand Medical College and Hospital, Ludhiana, Punjaben_US
dc.identifier.affiliationsEx-Scientist-G & Head, Division of Basic Medical Sciences, Indian Council of Medical Research, New Delhien_US
dc.identifier.affiliationsFormer National Chair in Clinical Pharmacology, Indian Council for Medical Research (ICMR), New Delhi; Chairperson SAG BMS, Member SAB, NIRRH, Mumbai, Maharashtra, Indiaen_US
dc.identifier.citationRanjalkar Jaya, Jhaj Ratinder, Chandy Sujith J, Bright Heber R, Chugh Preeta K, Tripathi Chakra D, Badyal Dinesh K, Balakrishnan Sadasivam, Medhi Bikash, Kamat Sandhya K, Tripathi Raakhi, Dikshit Harihar, Roy Sukalyan S, Chatterjee Suparna, Bhattacharjee Manjari, Trivedi Niyati, Desai Chetna, Gupta Pooja, Roy Atanu, Raveendran Ramasamy, Mathaiyan Jayanthi, Kaushal Sandeep, Jain Samriti, Kaul Rajni, Kshirsagar Nilima A. Usage Pattern of Fixed-dose Combinations at ICMR Network of Rational Use of Medicine Centres across India: Recommendations for Policymakers and Prescribers. Journal of the Association of Physicians of India. 2023 Feb; 71(2): 30-36en_US
dc.identifier.issn0004 – 5772
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/216350
dc.languageenen_US
dc.publisherAssociation of Physicians of Indiaen_US
dc.relation.issuenumber2en_US
dc.relation.volume71en_US
dc.source.urihttps://www.japi.org/x2e4e444/usage-pattern-of-fixed-dose-combinations-at-icmr-network-of-rational-use-of-medicine-centres-across-india-recommendations-for-policymakers-and-prescribersen_US
dc.titleUsage Pattern of Fixed-dose Combinations at ICMR Network of Rational Use of Medicine Centres across India: Recommendations for Policymakers and Prescribersen_US
dc.typeJournal Articleen_US
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