A case report of thrombotic microangiopathy in a patient with advanced pancreatic carcinoma: an emerging, rare, and serious complication

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dc.contributor.authorKandari, Sen_US
dc.contributor.authorSingh, Aen_US
dc.contributor.authorPuri, Ren_US
dc.contributor.authorCheriyan, Aen_US
dc.contributor.authorKaur, Sen_US
dc.date.accessioned2025-06-18T11:13:48Z
dc.date.available2025-06-18T11:13:48Z
dc.date.issued2025-06
dc.description.abstractThrombotic microangiopathies are characterized by microangiopathic hemolytic anemia and end-organ damage following endothelial injury. The chemotherapeutic agents used in malignancy are one of the important causes of secondary TMA. Both malignancy and TMA are associated with significant morbidity and mortality. Timely recognition of both can result in early target-specific treatment initiation and better outcomes for both diseases. Here, we present a case of TMA in a patient with stage 4 pancreatic carcinoma being treated with Gemcitabine presented with acute kidney disease with new-onset hypertension, edematous illness, and anemia. The patient was Hemodialysis dependent and was treated with steroids, plasma exchange, and rituximab. The patient remained HD dependent 6 months post-treatment and was declared ESRD. Highlighting the importance of early recognition and timely treatment initiation.en_US
dc.identifier.affiliationsDepartment of Nephrology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, Indiaen_US
dc.identifier.affiliationsDepartment of Nephrology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, Indiaen_US
dc.identifier.affiliationsDepartment of Nephrology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, Indiaen_US
dc.identifier.affiliationsDepartment of Nephrology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, Indiaen_US
dc.identifier.affiliationsDepartment of Nephrology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, Indiaen_US
dc.identifier.citationKandari S, Singh A, Puri R, Cheriyan A, Kaur S. A case report of thrombotic microangiopathy in a patient with advanced pancreatic carcinoma: an emerging, rare, and serious complication. International Journal of Advances in Medicine. 2025 Jun; 12(3): 308-310en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/248363
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.18203/2349-3933.ijam20251081en_US
dc.subjectThrombotic microangiopathyen_US
dc.subjectGemcitabine induced-TMAen_US
dc.subjectAcute kidney diseaseen_US
dc.subjectPlasmapheresisen_US
dc.subjectChemotherapy-associated complicationen_US
dc.titleA case report of thrombotic microangiopathy in a patient with advanced pancreatic carcinoma: an emerging, rare, and serious complicationen_US
dc.typeJournal Articleen_US
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