A Pilot Study to Evaluate the Effects of Cerebroprotein Hydrolysate on Neurological Outcomes and Hospital Stay in Patients Admitted for Ischemic and Hemorrhagic Stroke

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dc.contributor.authorAshraf, M Uwaisen_US
dc.contributor.authorParveen, Nikhaten_US
dc.contributor.authorAshraf, M Uzairen_US
dc.contributor.authorBharadwaj, Divyashsishen_US
dc.contributor.authorBharadwaj, Devashsishen_US
dc.contributor.authorAbbasi, Areeben_US
dc.date.accessioned2023-08-09T06:14:09Z
dc.date.available2023-08-09T06:14:09Z
dc.date.issued2023-02
dc.description.abstractIntroduction: Neurological stroke is the most common cause of disability and leaves nearly 65% of survivors with sensory, motor and coordinative disabilities. At present, there are no therapies to prevent long-term neurological deficits after stroke. Many neuroprotective drugs are being tested with the aim to ensure these effects. Preclinical studies have shown a modulatory effect of cerebroprotein hydrolysate on synaptic remodeling and facilitated synaptic transmission. Material and methods: This was a hospital-based, open-label pilot study conducted in a tertiary care hospital of North India. All patients admitted with a diagnosis of stroke both ischemic and hemorrhagic, were included in the study. Patients were randomized into two groups. The test group was given cerebroprotein hydrolysate, along with standard treatment for stroke, whereas the other group was kept on standard treatment for stroke as per the latest guidelines, without cerebroprotein. Results: A total of 50 patients of stroke, admitted in a tertiary care center were included in the study. The mean age of the patients was 65.7 ± 11.86 years. Twenty-six (52%) were males and 24 (48%) were females. Out of the total 50 patients, 23 (46%) had ischemic stroke and 27 (54%) had hemorrhagic stroke. Twenty (40%) had diabetes, 37 (74%) had hypertension, 8 (16%) were known cases of coronary artery disease, 28 (56%) had dyslipidemia, 22 (44%) were smokers, 7 (14%) had a history of ethanol consumption and 13 (26%) were obese. Mean Barthel score at admission was 21.2 ± 11.3 and mean Rankin score at admission was 3.6 ± 1.37. Mean Barthel score at end of treatment was 53.9 ± 28.72 and mean Rankin score at end of treatment was 2.6 ± 1.65. The mean duration of admission was 6.8 ± 3.57 days. Conclusion: The current study highlights the role of cerebroprotein hydrolysate in improving the neurological scores and reducing hospital stay among patients hospitalized with stroke.en_US
dc.identifier.affiliationsAssistant Professor, Dept. of Medicineen_US
dc.identifier.affiliationsInternen_US
dc.identifier.affiliationsResearch Scholaren_US
dc.identifier.affiliationsMBBS Student JN Medical College, AMU, Aligarh, Uttar Pradeshen_US
dc.identifier.citationAshraf M Uwais, Parveen Nikhat, Ashraf M Uzair, Bharadwaj Divyashsish, Bharadwaj Devashsish, Abbasi Areeb. A Pilot Study to Evaluate the Effects of Cerebroprotein Hydrolysate on Neurological Outcomes and Hospital Stay in Patients Admitted for Ischemic and Hemorrhagic Stroke. Indian Journal of Clinical Practice. 2023 Feb; 33(9): 25-29en_US
dc.identifier.issn0971-0876
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/222144
dc.languageenen_US
dc.publisherIJCP Groupen_US
dc.relation.issuenumber9en_US
dc.relation.volume33en_US
dc.source.urihttps://ijcp.in/Pages/Post_Detail.aspx?wid=20521&A%20Pilot%20Study%20to%20Evaluate%20the%20Effects%20of%20Cerebroprotein%20Hydrolysate%20on%20Neurological%20Outcomes%20and%20Hospital%20Stay%20in%20Patients%20Admitted%20for%20Ischemic%20and%20Hemorrhagic%20Strokeen_US
dc.subjectBarthel scoreen_US
dc.subjectRankin scoreen_US
dc.subjectneuroprotectiveen_US
dc.subjectneurological deficiten_US
dc.titleA Pilot Study to Evaluate the Effects of Cerebroprotein Hydrolysate on Neurological Outcomes and Hospital Stay in Patients Admitted for Ischemic and Hemorrhagic Strokeen_US
dc.typeJournal Articleen_US
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