Brain metastasis--evidence based management.

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dc.contributor.authorBiswas, Gen_US
dc.contributor.authorBhagwat, Ren_US
dc.contributor.authorKhurana, Ren_US
dc.contributor.authorMenon, Hen_US
dc.contributor.authorPrasad, Nen_US
dc.contributor.authorParikh, P Men_US
dc.date.accessioned2006-01-14en_US
dc.date.accessioned2009-06-01T16:27:20Z
dc.date.available2006-01-14en_US
dc.date.available2009-06-01T16:27:20Z
dc.date.issued2006-01-14en_US
dc.description87 references.en_US
dc.description.abstractAdvances in cancer management have resulted in a significant increase in median survival of number of diseases. Consequently we are seeing more patients living long enough to develop symptomatic brain metastases. The management of such patients will be discussed here. The most important definitive investigation is contrast enhanced MRI scan of brain. Management consists of supportive care and disease directed treatment. Surgical resection remains the gold standard for the treatment of solitary brain metastases. Whole brain radiotherapy is considered standard treatment for all patients with brain metastases. The role of chemotherapy was limited in the past. Recently several new agents have been identified as potentially useful. Preliminary results indicate that drugs like temozolomide and topotecan have antitumor activity against the brain metastases as well as the primary systemic malignancies. The goal of multimodality treatment for brain metastases is to palliate local symptoms and prevent consequences of neurological involvement.en_US
dc.description.affiliationDepartment of Medical Oncology, Tata Memorial Hospital, Parel, Mumbai-400 012, India.en_US
dc.identifier.citationBiswas G, Bhagwat R, Khurana R, Menon H, Prasad N, Parikh PM. Brain metastasis--evidence based management. Journal of Cancer Research and Therapeutics. 2006 Jan-Mar; 2(1): 5-13en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/111564
dc.language.isoengen_US
dc.source.urihttps://www.cancerjournal.neten_US
dc.subject.meshBrain Neoplasms --physiopathologyen_US
dc.subject.meshEvidence-Based Medicineen_US
dc.subject.meshHumansen_US
dc.titleBrain metastasis--evidence based management.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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