Association of human leucocyte DR and DQ antigens in Crohn's disease in Asian Indians: a family study.

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dc.contributor.authorThakur, Seemaen_US
dc.contributor.authorRanjan, Piyushen_US
dc.contributor.authorGhoshal, U Cen_US
dc.contributor.authorMuller-Myhsok, Bertamen_US
dc.contributor.authorKhan, Faisalen_US
dc.contributor.authorTalwar, Sudhaen_US
dc.contributor.authorAgarwal, Surakshaen_US
dc.date.accessioned2003-10-29en_US
dc.date.accessioned2009-06-04T03:15:37Z
dc.date.available2003-10-29en_US
dc.date.available2009-06-04T03:15:37Z
dc.date.issued2003-10-29en_US
dc.description.abstractThe pathogenesis of Crohn's disease (CD) involves an abnormal immune response to enteric bacteria in genetically susceptible individuals. There are no family studies regarding the association of CD with human leucocyte antigens (HLA) class II. In the present study, we have studied the association of HLA class II antigens in patients with CD and their first-degree relatives. Nine patients with CD and their first-degree relatives were studied. A group of 110 healthy unrelated and ethnically matched subjects were used as controls. Molecular HLA typing was done using the sequence-specific primer-based method. The transmission disequilibrium test (TDT) was used to analyze the results. A total of 65 individuals were included in the study; 52/56 first-degree relatives (92.8%) of 9 patients with CD consented to the study. The median age of patients was 40 years. When the distribution of the HLA class II antigens in patients was compared to that in controls no significant differences were observed even after applying the Yates correction. As the sample size of the population was small, the association of CD with DR and DQ alleles was further analyzed by using the TDT. Even after applying TDT, no significant association was observed. Familial aggregation of CD is uncommon in India. Crohn disease is not associated with HLA class II antigens in Indian patients. Genes of the major histocompatiblity complex are likely to contribute little to the susceptibility to Crohn disease in Indian patients.en_US
dc.description.affiliationDepartment of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareili Road, Lucknow 226014.en_US
dc.identifier.citationThakur S, Ranjan P, Ghoshal UC, Muller-Myhsok B, Khan F, Talwar S, Agarwal S. Association of human leucocyte DR and DQ antigens in Crohn's disease in Asian Indians: a family study. Tropical Gastroenterology. 2003 Oct-Dec; 24(4): 185-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/124161
dc.language.isoengen_US
dc.source.urihttps://www.tropicalgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCrohn Disease --epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Predisposition to Diseaseen_US
dc.subject.meshHLA-DQ Antigens --geneticsen_US
dc.subject.meshHLA-DR Antigens --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleAssociation of human leucocyte DR and DQ antigens in Crohn's disease in Asian Indians: a family study.en_US
dc.typeJournal Articleen_US
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