Immature teratoma of the ovary: A clinicopathological study of 28 cases.

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dc.contributor.authorDeodhar, Kedar K
dc.contributor.authorSuryawanshi, Pallavi
dc.contributor.authorShah, Milap
dc.contributor.authorRekhi, Bharat
dc.contributor.authorChinoy, R F
dc.date.accessioned2012-10-12T09:34:32Z
dc.date.available2012-10-12T09:34:32Z
dc.date.issued2011-10
dc.description.abstractAim: Immature teratoma (IT) of the ovary represents 1% of all ovarian cancers and 20% of malignant ovarian germ cell tumors. This retrospective study of 28 such cases aims to look at its morphological spectrum and to study the correlation of the grade and stage of the tumor with prognosis. Materials and Methods: A retrospective study of 28 cases of IT of the ovary was done. Neuroepithelium was graded as grade I, II and III according to the standard criteria. The presence of immature mesenchyme was also looked for and similarly graded. Results: The median age for the cases was 19 years and abdominal pain was the commonest symptom. Neuroepithelium was seen in 26 cases (6 were grade I, 13 were grade II, and 7 were grade III); and two showed immature mesenchymal tissue (IM) only. IM was seen in all 28 cases, but no correlation with the grade of the IT of the ovary is found. The follow up is available in 23 cases ranging from 6 months to 78 months (median 33 months). Of these, 13 were stage I, 3 were stage II and 7 were stage III ITs. Out of 23 patients, 17 patients were alive without evidence of disease recurrence during the last follow up. Adverse events in the form of death and local recurrence occurred in 6 patients. One patient died of the disease at 7 months duration from the disease onset (stage III, grade II IT). Conclusion: Morphological spectrum of IT of ovary is varied. Immature mesenchyme was seen in all the cases of IT of ovary and its presence should prompt a careful search for immature neuroepithelium. Stage I IT of ovary has better prognosis. Combination of surgery and chemotherapy can give longer survival even in recurrent disease.en_US
dc.identifier.citationDeodhar Kedar K, Suryawanshi Pallavi, Shah Milap, Rekhi Bharat, Chinoy R F. Immature teratoma of the ovary: A clinicopathological study of 28 cases. Indian Journal of Pathology & Microbiology. 2011 Oct-Dec 54(4): 730-735.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142100
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=4;spage=730;epage=735;aulast=Deodharen_US
dc.subjectAlfa feto proteinen_US
dc.subjectimmature teratomaen_US
dc.subjectimmature mesenchymal tissueen_US
dc.subjectneuroepithelium, ovaryen_US
dc.subjectsalpingo-opherectomyen_US
dc.subjectyolk sac tumoren_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAntineoplastic Agents --therapeutic use
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshOvarian Neoplasms --drug therapy
dc.subject.meshOvarian Neoplasms --pathology
dc.subject.meshOvarian Neoplasms --surgery
dc.subject.meshPrognosis
dc.subject.meshRetrospective Studies
dc.subject.meshSeverity of Illness Index
dc.subject.meshSurvival Analysis
dc.subject.meshTeratoma --drug therapy
dc.subject.meshTeratoma --pathology
dc.subject.meshTeratoma --surgery
dc.subject.meshYoung Adult
dc.titleImmature teratoma of the ovary: A clinicopathological study of 28 cases.en_US
dc.typeArticleen_US
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