Study of Organisms Causing Osteomyelitis in a Tertiary Care Hospital.

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dc.contributor.authorMeshram, Rupali Bhauraoen_US
dc.contributor.authorGajbhiye, Sunita Rajen_US
dc.contributor.authorRaut, Sharmila Sanjayen_US
dc.date.accessioned2020-11-18T10:18:49Z
dc.date.available2020-11-18T10:18:49Z
dc.date.issued2020-01
dc.description.abstractBACKGROUND The term osteomyelitis (OSM) was first used by the French surgeon Edouard Chassaignac in 1852, who defined the disease as an inflammatory process accompanied by bone destruction caused by an infecting microorganism.The clinical manifestation and the natural history of OSM depend on several factors. OSM mostly affects the growing ends of long bones.We wanted to study the organisms causing osteomyelitis and their antimicrobial susceptibility pattern.METHODSPus and bone aspirate were collected from 115 diagnosed patients of osteomyelitis and were processed for isolation of organisms by standard microbiological techniques. Isolates were identified by various biochemical reactions and were subjected to antimicrobial susceptibility test as per CLSI guidelinesby Kirby-Bauer disk diffusion technique on Mueller Hinton agar (MHA). Data collected in the questionnaire was entered and analysed in Epi Info software version 7.2.RESULTSIn 101 samples, 116 organisms were isolated. In 14 samples no organism was isolated, which can be attributed to the viral aetiology, parasites and anaerobes. Acute Osteomyelitis (AOSM) was found to be more common in the age group of 1-10 years, whereas chronic osteomyelitis (COSM) was found more commonly in 21-30 and 31-40 years age group. Male to Female ratio was 2.2:1. Bones involved in AOSM and COSM were mostly femur followed by tibia and humerus. S. aureus was the most predominant isolate. All the isolates of S. aureus showed 100% sensitivity to Vancomycin, Amikacin, Netilmicin, Chloramphenicol. Out of 48 isolates of S. aureus, 37.50% were MRSA, 6.25% were ICR, 14.58% were MRSA+ICR found.CONCLUSIONSOsteomyelitis is found to be highest in third decade, with the males being predominantly affected. Acute osteomyelitis is predominantly seen in children, whereas chronic osteomyelitis in adults. Even though Staphylococcus aureus has always remained the most common etiological agent of osteomyelitis, increasing infections due to Gram negative bacilli and even poly-microbial infections are gaining importance. MRSA infection is known to increase post-operative complications. Introduction of MBL or carbapenemase production in Gram negative bacilli is a matter of great concern. Timely knowledge of aetiology and antimicrobial resistance pattern of osteomyelitis isolates can help in rational use of antibiotics and control of drug resistance.en_US
dc.identifier.affiliationsDepartment of Microbiology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India.en_US
dc.identifier.affiliationsDepartment of Microbiology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India.en_US
dc.identifier.affiliationsDepartment of Microbiology, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India.en_US
dc.identifier.citationMeshram Rupali Bhaurao, Gajbhiye Sunita Raj, Raut Sharmila Sanjay. Study of Organisms Causing Osteomyelitis in a Tertiary Care Hospital.. Journal of Evolution of Medical and Dental Sciences. 2020 Jan; 9(1): 33-37en_US
dc.identifier.issn2278-4802
dc.identifier.issn2278-4748
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215347
dc.languageenen_US
dc.publisherAkshantala Enterprises Private Limiteden_US
dc.relation.issuenumber1en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org//10.14260/jemds/2020/8en_US
dc.subjectOsteomyelitisen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectMRSAen_US
dc.subjectLong Bonesen_US
dc.subjectMalesen_US
dc.titleStudy of Organisms Causing Osteomyelitis in a Tertiary Care Hospital.en_US
dc.typeJournal Articleen_US
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