Correlation of Vitamin D Levels with COVID-19 Severity and Outcome

Simple item page
dc.contributor.authorKaur, Gurdeepen_US
dc.contributor.authorSharma, Gauraven_US
dc.contributor.authorSharma, Jainendraen_US
dc.contributor.authorBiyani, Shwetaen_US
dc.contributor.authorVeerwal, Ranjnaen_US
dc.date.accessioned2023-08-09T06:13:39Z
dc.date.available2023-08-09T06:13:39Z
dc.date.issued2022-06
dc.description.abstractBackground and aims: Low vitamin D levels have been associated with an increase in inflammatory cytokines and a significantly increased risk of pneumonia and viral upper respiratory tract infections. Vitamin D deficiency is associated with an increase in thrombotic episodes, which are frequently observed in coronavirus disease 2019 (COVID-19). These conditions are reported to carry a higher mortality in COVID-19. So, we conducted a study to prove the correlation of vitamin D levels with COVID-19 infection and severity. Material and methods: The present study was conducted at RNT Medical College, Udaipur, Rajasthan. This study was done over a period of 2 months after getting approval from Institutional Ethics Committee. Written and informed consent was obtained from patients. In this study, 81 patients admitted in COVID wards and ICU, with COVID reverse transcriptase-polymerase chain reaction (RT-PCR) positive reports were included. Results: Out of a total 81 patients, 37 (45.7%) were in the 41-60 years age group, 29 (35.8%) were more than 60 years of age and 15 (18.5%) were less than 40 years of age. Seventeen patients had severe vitamin D deficiency, 27 patients had moderate vitamin D deficiency, 20 patients had mild vitamin D deficiency and 17 patients had normal vitamin D level. Out of 17 patients who had severe vitamin D deficiency, 11 (64.7%) patients required invasive mechanical ventilation and out of these 17 patients, 13 (76.47%) patients died. Out of 17 patients who had normal level of vitamin D, 16 (94.1%) maintained SpO2 at room air and only 1 patient required invasive mechanical ventilation. As the level of vitamin D increased from severely low to normal level, requirement of high oxygen support decreased and SpO2 at room air increased. Mean of vitamin D among the patients who died was 10.4963 while mean of vitamin D level among patients who survived and were discharged was 27.2362. All 17 patients who had normal level of vitamin D were discharged from the hospital. Mean of serum ferritin and mean of interleukin (IL)-6 was high in patients who died and low in patients who were discharged. Conclusions: Vitamin D level plays an important role in COVID-19 disease. Vitamin D have significant role in protection from severe form of disease.en_US
dc.identifier.affiliationsProfessor, Dept. of Medicineen_US
dc.identifier.affiliationsSenior Resident, Dept. of General Medicineen_US
dc.identifier.affiliationsAssociate Professor, Dept. of Biochemistry RNT Medical College, Udaipur, Rajasthanen_US
dc.identifier.citationKaur Gurdeep, Sharma Gaurav, Sharma Jainendra, Biyani Shweta, Veerwal Ranjna. Correlation of Vitamin D Levels with COVID-19 Severity and Outcome. Indian Journal of Clinical Practice. 2022 Jun; 33(1): 30-34en_US
dc.identifier.issn0971-0876
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/222065
dc.languageenen_US
dc.publisherIJCP Groupen_US
dc.relation.issuenumber1en_US
dc.relation.volume33en_US
dc.source.urihttps://ijcp.in/Pages/Post_Detail.aspx?wid=20388&Correlation%20of%20Vitamin%20D%20Levels%20with%20COVID-19%20Severity%20and%20Outcomeen_US
dc.subjectCOVID-19en_US
dc.subjectvitamin Den_US
dc.subjectT regulatory lymphocytesen_US
dc.subjectacute respiratory distress syndromeen_US
dc.subjectIL-6en_US
dc.subjectserum ferritinen_US
dc.titleCorrelation of Vitamin D Levels with COVID-19 Severity and Outcomeen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
IJCP2022v33n1p30.pdf
Size:
343.35 KB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Clinical Practice