Immunomodulation with corticosteroids and levamisole in leprosy as gauged by in vivo lepromin and in vitro CMI responses.

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dc.contributor.authorKundu, S Ken_US
dc.contributor.authorHazra, S Ken_US
dc.contributor.authorChaudhuri, S Ken_US
dc.contributor.authorNandy, Aen_US
dc.date.accessioned1985-01-01en_US
dc.date.accessioned2009-05-28T10:18:48Z
dc.date.available1985-01-01en_US
dc.date.available2009-05-28T10:18:48Z
dc.date.issued1985-01-01en_US
dc.description.abstractCorticosteroids and Levamisole are known to be immuno suppressive and immuno stimulating agents respectively. Their effects on polar types of leprosy, tuberculoid and lepromatous have been studied using in vivo lepromin and in vitro lymphocyte count, rosette formation, L.T.T. and L.M.I.T. parameters. Immunosuppressive effect of corticosteroids on tuberculoid leprosy is marked with reduced and negative lepromin sensitivity but same does not hold true with other in vitro C.M.I. tests. Similar results are obtained with levamisole exhibiting its ineffectiveness in lepromin conversion in lepromatous cases although some improvement is observed in other in vitro C.M.I. tests. Evaluation of the results showed: lack of correlation between in vivo lepromin and in vitro other C.M.I. parameters with corticosteroids and levamisole lepromin sensitivity has some unknown influence other than thymic factors, prolonged corticosteroid therapy may produce permanent immunosuppression in tuberculoid cases making them more vulnerable towards lepromatous pole and lepromin sensitivity is more reliable, stable and easy to perform.en_US
dc.identifier.citationKundu SK, Hazra SK, Chaudhuri SK, Nandy A. Immunomodulation with corticosteroids and levamisole in leprosy as gauged by in vivo lepromin and in vitro CMI responses. Indian Journal of Leprosy. 1985 Jan-Mar; 57(1): 37-57en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/55150
dc.language.isoengen_US
dc.subject.meshAdrenal Cortex Hormones --pharmacologyen_US
dc.subject.meshCell Migration Inhibitionen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunity, Cellular --drug effectsen_US
dc.subject.meshLepromin --immunologyen_US
dc.subject.meshLeprosy --immunologyen_US
dc.subject.meshLeukocyte Counten_US
dc.subject.meshLeukocytes --immunologyen_US
dc.subject.meshLevamisole --pharmacologyen_US
dc.subject.meshLymphocytesen_US
dc.subject.meshMacrophages --immunologyen_US
dc.titleImmunomodulation with corticosteroids and levamisole in leprosy as gauged by in vivo lepromin and in vitro CMI responses.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
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