Analytical Study of Ocular Surface Changes in Patients of Chronic Kidney Disease undergoing Hemodialysis and Peritoneal Dialysis

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dc.contributor.authorAhuja, Shashien_US
dc.contributor.authorJalwaniya, Shilpaen_US
dc.contributor.authorParameswaran, Sreejithen_US
dc.contributor.authorSarkar, Sonalien_US
dc.contributor.authorAnanthkrishnan, Rameshen_US
dc.contributor.authorGochhait, Debasisen_US
dc.date.accessioned2023-07-21T11:27:56Z
dc.date.available2023-07-21T11:27:56Z
dc.date.issued2022-10
dc.description.abstractObjectives?The idiopathic group is a significant cause of chronic kidney disease (CKD) in developing countries. Literature available on ocular surface changes has predominantly been reported in patients undergoing hemodialysis. Little is known about the changes in patients undergoing peritoneal dialysis. The present study aimed to identify ocular surface changes in an idiopathic group of CKD undergoing dialysis. Aim?To compare tear film disorders and the severity of ocular surface changes (goblet cell density, squamous metaplasia, and corneoconjunctival calcification) in patients of idiopathic etiology with CKD undergoing hemodialysis and peritoneal dialysis. This is an analytical study. Materials and Methods?Asymptomatic adult patients of idiopathic CKD, on treatment with dialysis underwent comprehensive ophthalmic examination, including best-corrected visual acuity, slit-lamp examination, and a dilated fundus examination. Dry eye assessment was done by ocular surface staining score, Schirmer test, and tear breakup time (TBUT). Conjunctival impression cytology was studied to assess changes on ocular surface. Chest X-rays for aortic calcification were reviewed and data analyzed. Results?Both eyes of 76 patients of hemodialysis and 32 patients of peritoneal dialysis were studied. Ocular surface staining (OSS) scores were low. Impression cytology showed a drop in goblet cell density, presence of squamous metaplasia, and conjunctival keratinization significantly more in the hemodialysis group. No correlation was seen between the presence of conjunctival calcification and aortic calcification. Conclusion?The hemodialysis group had mild subclinical dry eye but keratinization of conjunctiva was seen. Similarly, advanced squamous metaplasia was seen in the peritoneal dialysis group. These changes were positively correlated to decrease in goblet cell density.en_US
dc.identifier.affiliationsDepartment of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Nephrology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Radiodiagnosis, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, Indiaen_US
dc.identifier.citationAhuja, Shashien_US
dc.identifier.citationJalwaniya, Shilpaen_US
dc.identifier.citationParameswaran, Sreejithen_US
dc.identifier.citationSarkar, Sonalien_US
dc.identifier.citationAnanthkrishnan, Rameshen_US
dc.identifier.citationGochhait, Debasis. Analytical Study of Ocular Surface Changes in Patients of Chronic Kidney Disease undergoing Hemodialysis and Peritoneal Dialysis. Annals of the National Academy of Medical Sciences. 2022 Oct; 58(4): 189-196en_US
dc.identifier.issn0379-038X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/220195
dc.languageenen_US
dc.publisherThieme Medical and Scientific Publishers Pvt. Ltden_US
dc.relation.issuenumber4en_US
dc.relation.volume58en_US
dc.source.urihttps://doi.org/10.1055/s-0042-1757736en_US
dc.subjectchronic kidney diseaseen_US
dc.subjectrenal dialysisen_US
dc.subjectimpression cytologyen_US
dc.subjectconjunctival keratinizationen_US
dc.subjectsquamous metaplasiaen_US
dc.subjectcalcificationen_US
dc.titleAnalytical Study of Ocular Surface Changes in Patients of Chronic Kidney Disease undergoing Hemodialysis and Peritoneal Dialysisen_US
dc.typeJournal Articleen_US
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