Extramedullary involvement in acute lymphoblastic leukemia and its relation to therapy.

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dc.contributor.authorRao, A Ven_US
dc.contributor.authorVerma, Ken_US
dc.contributor.authorKapila, Ken_US
dc.contributor.authorChoudhry, V Pen_US
dc.contributor.authorPati, H Pen_US
dc.date.accessioned1991-07-01en_US
dc.date.accessioned2009-05-30T11:56:45Z
dc.date.available1991-07-01en_US
dc.date.available2009-05-30T11:56:45Z
dc.date.issued1991-07-01en_US
dc.description.abstractExtramedullary involvement (EMI) of various body sites was studied by doing CSF cytology anu FNAC of testes and lymph nodes in 82 children with acute lymphoblastic leukemia (ALL). Forty-five patients had received no therapy (group I) and 37 had been diagnosed and treated earlier and were now in remission (36) or relapse (group II). EMI was documented in 48.9% and 32.4% of patients of group I and II respectively. EMI was seen more frequently in patients with FAB-L 2 subtype (66.6%) as compared to FAB-L1 subtype (34.6%) in group I. Lymph nodes and testes were commonly involved in group I and II patients respectively. Successful remission after complete chemotherapy was achieved in 82.5% of group I patients. However, successful remission rates were 95.2% in patients without any evidence of EMI versus 68.4% in those with EMI. These differences were also observed when response to therapy was analysed separately for patients with FAB-L1 and FAB-L2 subtypes.en_US
dc.description.affiliationDepartment of Pathology, All India Institute of Medical Sciences, New Delhi.en_US
dc.identifier.citationRao AV, Verma K, Kapila K, Choudhry VP, Pati HP. Extramedullary involvement in acute lymphoblastic leukemia and its relation to therapy. Indian Journal of Pediatrics. 1991 Jul-Aug; 58(4): 535-41en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/80188
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAdolescenten_US
dc.subject.meshCentral Nervous System Neoplasms --therapyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMedulla Oblongata --pathologyen_US
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma --therapyen_US
dc.subject.meshPrognosisen_US
dc.subject.meshTestis --pathologyen_US
dc.titleExtramedullary involvement in acute lymphoblastic leukemia and its relation to therapy.en_US
dc.typeJournal Articleen_US
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