Narrative Review of Systemic Inflammatory Response Mechanisms in Cardiac Surgery and Immunomodulatory Role of Anesthetic Agents

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dc.contributor.authorMaisat, Wiriyaen_US
dc.contributor.authorYuki, Koichien_US
dc.date.accessioned2023-07-14T08:01:16Z
dc.date.available2023-07-14T08:01:16Z
dc.date.issued2023-06
dc.description.abstractAlthough surgical techniques and perioperative care have made significant advances, perioperative mortality in cardiac surgery remains relatively high. Single? or multiple?organ failure remains the leading cause of postoperative mortality. Systemic inflammatory response syndrome (SIRS) is a common trigger for organ injury or dysfunction in surgical patients. Cardiac surgery involves major surgical dissection, the use of cardiopulmonary bypass (CPB), and frequent blood transfusions. Ischemia?reperfusion injury and contact activation from CPB are among the major triggers for SIRS. Blood transfusion can also induce proinflammatory responses. Here, we review the immunological mechanisms of organ injury and the role of anesthetic regimens in cardiac surgeryen_US
dc.identifier.affiliationsDivision of Cardiac Anesthesia, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children抯 Hospitalen_US
dc.identifier.affiliationsDepartments of Anaesthesia anden_US
dc.identifier.affiliationsImmunology, Harvard Medical School, Boston, USAen_US
dc.identifier.affiliationsDepartment of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailanden_US
dc.identifier.citationMaisat Wiriya, Yuki Koichi. Narrative Review of Systemic Inflammatory Response Mechanisms in Cardiac Surgery and Immunomodulatory Role of Anesthetic Agents. International Journal of Medical Research & Health Sciences. 2023 Jun; 26(2): 133-142en_US
dc.identifier.issn0974-5181
dc.identifier.issn0971-9784
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/219285
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber2en_US
dc.relation.volume26en_US
dc.source.urihttps://doi.org/10.4103/aca.aca_147_22en_US
dc.subjectCardiac surgeryen_US
dc.subjectcardiopulmonary bypassen_US
dc.subjectmortalityen_US
dc.subjectorgan injuryen_US
dc.subjectvolatile anestheticsen_US
dc.titleNarrative Review of Systemic Inflammatory Response Mechanisms in Cardiac Surgery and Immunomodulatory Role of Anesthetic Agentsen_US
dc.typeJournal Articleen_US
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