A case series of sinonasal mucormycosis and actinomycosis infection: a clinicopathological approach

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dc.contributor.authorGupta, Arushien_US
dc.contributor.authorKhetrapal, Shaanen_US
dc.contributor.authorRana, Safiaen_US
dc.contributor.authorJairajpuri, Zeeba Shamimen_US
dc.contributor.authorKhan, Sabinaen_US
dc.contributor.authorJetley, Sujataen_US
dc.contributor.authorMonga, Seemaen_US
dc.date.accessioned2025-05-12T11:41:43Z
dc.date.available2025-05-12T11:41:43Z
dc.date.issued2024-12
dc.description.abstractBackground: Mucormycosis is a fast-progressing and life-threatening fungal infection caused by fungi belonging to the order Mucorales. It primarily affects individuals with weakened immune systems or diabetes mellitus (DM). Case Reports: This study includes eight patients aged from 24 to 68 years (six males and two females), all of whom presented to the ear, nose, and throat department with primary complaints of nasal obstruction. Histopathological evaluation of biopsies confirmed mucormycosis, revealing areas of necrosis. After appropriate treatment, all patients showed improvement. Discussion: Histopathological examination is the gold standard for diagnosing fungal infections like mucormycosis and actinomycosis. Hematoxylin and eosin staining typically shows necrotic tissue, a mix of acute and chronic inflammatory cells, and broad, nonseptate fungal hyphae. Conclusion: Mucormycosis is the third most common angioinvasive fungal infection and carries a high mortality rate. Successful management requires early diagnosis, aggressive surgical intervention, and timely antifungal therapy. Additionally, controlling underlying conditions, such as DM, is critical in both preventing and treating this serious infection. This case series underscores the importance of thorough histopathological evaluation and heightened clinical awareness when diagnosing and managing sinonasal infections in immunocompromised patients.en_US
dc.identifier.affiliationsDepartment of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Otolaryngology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, Indiaen_US
dc.identifier.citationGupta Arushi, Khetrapal Shaan, Rana Safia, Jairajpuri Zeeba Shamim, Khan Sabina, Jetley Sujata, Monga Seema. A case series of sinonasal mucormycosis and actinomycosis infection: a clinicopathological approach. MGM Journal of Medical Sciences. 2024 Dec; 11(4): 645-650en_US
dc.identifier.issn2347-7946
dc.identifier.issn2347-7962
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247740
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber4en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.4103/mgmj.mgmj_79_24en_US
dc.subjectActinomycosisen_US
dc.subjectimmunocompromiseden_US
dc.subjectmanagementen_US
dc.subjectmucormycosisen_US
dc.subjectsinonasal obstructionen_US
dc.titleA case series of sinonasal mucormycosis and actinomycosis infection: a clinicopathological approachen_US
dc.typeJournal Articleen_US
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