Spectrum of hemostatic derangements, in Budd-Chiari syndrome.

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dc.contributor.authorPati, Hara Prasaden_US
dc.contributor.authorDayal, Sanjanaen_US
dc.contributor.authorSrivastava, Amitaen_US
dc.contributor.authorPande, Girish Kumaren_US
dc.contributor.authorAcharya, Subrat Kumaren_US
dc.date.accessioned2003-03-17en_US
dc.date.accessioned2009-05-29T02:01:55Z
dc.date.available2003-03-17en_US
dc.date.available2009-05-29T02:01:55Z
dc.date.issued2003-03-17en_US
dc.description.abstractBACKGROUND: Hemostatic abnormalities have been reported in various hepatocellular diseases. We evaluated the hemostatic functions in patients with Budd-Chiari syndrome. METHODS: Biochemical liver function tests, and measurement of prothrombin time, activated partial thromboplastin time, and plasma levels of anti-thrombin III (antigen) and activity of protein C were done in 36 patients with Budd-Chiari syndrome. RESULTS: Liver biochemistry was abnormal in 34 patients. Plasma prothrombin time and activated partial thromboplastin time were prolonged in 17 (47%) and 23 (64%) patients, respectively. Antithrombin III antigen levels and protein C activity were reduced in 15 (50%) and 25 (83%) patients, respectively, among the 30 patients studied. Albumin levels showed significant correlation with coagulation test results, levels of anti-thrombin-III, and protein C activity. CONCLUSION: Hepatic synthesis of coagulation factors and anticoagulants is reduced in Budd-Chiari syndrome; this may play a role in recurrence of thrombosis.en_US
dc.description.affiliationDepartment of Hematology, All India Institute of Medical Sciences, New Delhi 110 029. harappati@yahoo.comen_US
dc.identifier.citationPati HP, Dayal S, Srivastava A, Pande GK, Acharya SK. Spectrum of hemostatic derangements, in Budd-Chiari syndrome. Indian Journal of Gastroenterology. 2003 Mar-Apr; 22(2): 59-60en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63651
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshBudd-Chiari Syndrome --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHemostasisen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Function Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshPartial Thromboplastin Timeen_US
dc.titleSpectrum of hemostatic derangements, in Budd-Chiari syndrome.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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