Differentiation of dementia with Lewy bodies, Alzheimer's disease and vascular dementia by cardiac 131I-meta-iodobenzylguanidine (MIBG) uptake (preliminary report).

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dc.contributor.authorJindahra, Panithaen_US
dc.contributor.authorVejjajiva, Athasiten_US
dc.contributor.authorWitoonpanich, Rawiphanen_US
dc.contributor.authorSirisriro, Rojanaen_US
dc.contributor.authorSritara, Chanikaen_US
dc.contributor.authorPulkes, Teeratornen_US
dc.date.accessioned2009-05-27T22:03:00Z
dc.date.available2009-05-27T22:03:00Z
dc.date.issued2004-10-25en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: Differentiation of dementia with Lewy bodies (DLB), vascular dementia (VAD), and Alzheimer's disease (AD) is difficult in clinical practice. Several new techniques have been used for differentiation of various types of dementia. Among these techniques 123I-meta-iodobenzylguanidine (MIBG) uptake was reported to have benefit in distinguishing DLB from AD. The authors study the role of MIBG as a tool for differentiation of DLB, AD and VAD. METHOD: Patients with dementia were recruited to the study by DSMIIIR criteria. Diagnosis of each dementia type was made by standard clinical criteria. Brain imagings and 131I-MIBG uptake were performed in all the studied patients. RESULTS: Five DLB, 3 AD and 3 VAD patients were clinically diagnosed. The heart/mediastinum (H/M) ratio in 4 out of 5 in DLB was significantly lower than H/M ratio in patients with AD and VAD. AD patients had the highest uptake of MIBG MIBG uptake of VAD patients was in the range between AD and DLB but the values were close to the AD group. CONCLUSIONS: 131I-MIBG is helpful in differentiating DLB from AD.en_US
dc.description.affiliationDivision of Neurology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.en_US
dc.identifier.citationJindahra P, Vejjajiva A, Witoonpanich R, Sirisriro R, Sritara C, Pulkes T. Differentiation of dementia with Lewy bodies, Alzheimer's disease and vascular dementia by cardiac 131I-meta-iodobenzylguanidine (MIBG) uptake (preliminary report). Journal of the Medical Association of Thailand. 2004 Oct; 87(10): 1176-81en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/45856
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.mesh3-Iodobenzylguanidine --diagnostic useen_US
dc.subject.meshAgeden_US
dc.subject.meshBrain --metabolismen_US
dc.subject.meshDementia --diagnosisen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart --radionuclide imagingen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyocardium --metabolismen_US
dc.subject.meshRadiopharmaceuticals --diagnostic useen_US
dc.titleDifferentiation of dementia with Lewy bodies, Alzheimer's disease and vascular dementia by cardiac 131I-meta-iodobenzylguanidine (MIBG) uptake (preliminary report).en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
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