Correlation between hepatitis B genotypes, 1896 precore mutation, virus loads and liver dysfunction in an Indian population.

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dc.contributor.authorVivekanandan, Perumalen_US
dc.contributor.authorBissett, Saraen_US
dc.contributor.authorIjaz, Samreenen_US
dc.contributor.authorTeo, Chong Geeen_US
dc.contributor.authorSridharan, Gopalanen_US
dc.contributor.authorRaghuraman, Sukanyaen_US
dc.contributor.authorDaniel, Hubert Dariusen_US
dc.contributor.authorKavitha, Manohar Len_US
dc.contributor.authorDaniel, Dollyen_US
dc.contributor.authorChandy, George Men_US
dc.contributor.authorAbraham, Priyaen_US
dc.date.accessioned2008-07-01en_US
dc.date.accessioned2009-05-29T03:09:17Z
dc.date.available2008-07-01en_US
dc.date.available2009-05-29T03:09:17Z
dc.date.issued2008-07-01en_US
dc.description.abstractBACKGROUND/OBJECTIVES: Hepatitis B virus (HBV) genotypes may differ in pathogenicity. However, the interplay between different virus characteristics such as genotypes, mutants and virus loads has not been well studied . We investigated the association between HBV genotype, presence of 1896 precore mutation and HBV viral loads in patients with HBV-related liver disease. METHODS: One hundred and sixteen HBV DNA-seropositive patients attending a gastroenterology outpatient clinic and 107 HBV DNA-seropositive blood donors were recruited. The subjects were stratified as those with normal (Group I, n=164) and elevated (Group II, n=59) ALT levels. The HBV genotype and the presence of the 1896 precore mutation were determined, and plasma HBV DNA levels measured. RESULTS: Genotype C was more common in Group II than in Group I (10 (17%) vs. 4 (2.4%); p< 0.005). There was no relationship between the 1896 precore mutation and the HBV DNA levels. Subjects with genotype C (n=14) had higher HBV DNA levels than those with genotypes A (n=33) or D (n=158). CONCLUSIONS: The infecting genotype, but not the presence of 1896 precore mutation, correlates with HBV load. The association of genotype C with higher virus loads and with elevated ALT may point to a greater pathogenicity of this genotype.en_US
dc.description.affiliationDepartment of Clinical Virology, Christian Medical College, Vellore, India.en_US
dc.identifier.citationVivekanandan P, Bissett S, Ijaz S, Teo CG, Sridharan G, Raghuraman S, Daniel HD, Kavitha ML, Daniel D, Chandy GM, Abraham P. Correlation between hepatitis B genotypes, 1896 precore mutation, virus loads and liver dysfunction in an Indian population. Indian Journal of Gastroenterology. 2008 Jul-Aug; 27(4): 142-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/65000
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHepatitis B --geneticsen_US
dc.subject.meshHepatitis B virus --geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshLiver --physiopathologyen_US
dc.subject.meshLiver Diseases --geneticsen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshMutation --geneticsen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshViral Loaden_US
dc.titleCorrelation between hepatitis B genotypes, 1896 precore mutation, virus loads and liver dysfunction in an Indian population.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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