Single daily dose of carbimazole in the treatment of hyperthyroidism.

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dc.contributor.authorGupta, S Ken_US
dc.contributor.authorMithal, Aen_US
dc.contributor.authorGodbole, M Men_US
dc.date.accessioned1992-09-01en_US
dc.date.accessioned2009-06-03T06:58:16Z
dc.date.available1992-09-01en_US
dc.date.available2009-06-03T06:58:16Z
dc.date.issued1992-09-01en_US
dc.description.abstractBACKGROUND. The antithyroid drugs, methimazole and carbimazole, are conventionally used in divided daily doses. However, these drugs have a longer intrathyroidal than a plasma half-life. We undertook this prospective, controlled study, in an area of mild iodine deficiency, to compare the efficacy of a single daily dose of carbimazole with divided doses in the treatment of hyperthyroidism. METHODS. Nineteen patients with hyperthyroidism received 30 mg of carbimazole daily at bed time (group A) while 14 received 10 mg of carbimazole every 8 hours (group B). These patients were assessed clinically and biochemically by estimation of serum total thyroxine, total triiodothyronine and thyrotropin before and 1, 2, 3, 4 and 6 weeks after treatment. RESULTS. There was no significant difference between mean baseline concentrations of thyroxine and triiodothyronine. After 1, 2, 3, 4 and 6 weeks there was a decline in their concentrations which was similar in both groups (p > 0.05). Euthyroidism was achieved in 4.6 +/- 1.4 weeks (range 2-6 weeks) in group A and in 3.8 +/- 1.2 weeks (range 3-6 weeks) in group B (p > 0.05). CONCLUSIONS. We conclude that carbimazole in a single daily dose is an effective method for treating hyperthyroidism in an area of mild iodine deficiency and its efficacy is comparable to divided dose therapy. This practical and acceptable method of treatment can be specially useful in patients who find it difficult to remember to take divided doses.en_US
dc.description.affiliationSanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.en_US
dc.identifier.citationGupta SK, Mithal A, Godbole MM. Single daily dose of carbimazole in the treatment of hyperthyroidism. National Medical Journal of India. 1992 Sep-Oct; 5(5): 214-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/119400
dc.language.isoengen_US
dc.source.urihttps://www.nmji.inen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshCarbimazole --administration & dosageen_US
dc.subject.meshDrug Administration Scheduleen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperthyroidism --blooden_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshThyronines --blooden_US
dc.titleSingle daily dose of carbimazole in the treatment of hyperthyroidism.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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