Laboratory studies in coagulation disorders.

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dc.contributor.authorSaxena, Renuen_US
dc.contributor.authorKannan, Meganathanen_US
dc.contributor.authorChoudhry, Ved Pen_US
dc.date.accessioned2007-07-19en_US
dc.date.accessioned2009-05-30T14:11:42Z
dc.date.available2007-07-19en_US
dc.date.available2009-05-30T14:11:42Z
dc.date.issued2007-07-19en_US
dc.description.abstractIt is important to go in a stepwise approach to diagnose spectrum of bleeding disorders, so that minimum tests are undertaken to make a definitive diagnosis and to avoid unnecessary tests and laboratory load. Depending on the abnormalities observed in the short screening, extended screening tests can be performed followed by specialized diagnostic tests. Bleeding time is prolonged in thrombocytopenia and platelet function disorders (PFD). If platelet count is normal, extended screening tests such as RVVT, PF3 availability and clot retraction can be performed. Russel viper venom directly activates FX, in presence of PF3, is an indicator of common pathway of coagulation. However, if there is deficiency of PF3 as obtained in PFD and APTT PT are normal, its prolongation indicates PFD. These can be tested invitro by performing RVVT with and without inosithin it is highly suggestive of underlying PFD. In such cases, diagnostic tests for PFD such as platelet aggregation with ADP, ADR, AA, Collagen and Ristocetin can be performed followed by electron microscopy if possible. Few of the interesting cases also have been discussed in the text.en_US
dc.description.affiliationDepartment of Hematology, All India Institute of Medical Sciences, New Delhi, India. renusax@hotmail.comen_US
dc.identifier.citationSaxena R, Kannan M, Choudhry VP. Laboratory studies in coagulation disorders. Indian Journal of Pediatrics. 2007 Jul; 74(7): 649-55en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/82421
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAdolescenten_US
dc.subject.meshBlood Coagulation Disorders --diagnosisen_US
dc.subject.meshBlood Coagulation Tests --methodsen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.titleLaboratory studies in coagulation disorders.en_US
dc.typeJournal Articleen_US
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