Bronchoalveolar lavage study in victims of toxic gas leak at Bhopal.

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dc.contributor.authorVijayan, V Ken_US
dc.contributor.authorPandey, V Pen_US
dc.contributor.authorSankaran, Ken_US
dc.contributor.authorMehrotra, Yen_US
dc.contributor.authorDarbari, B Sen_US
dc.contributor.authorMisra, N Pen_US
dc.date.accessioned1989-12-01en_US
dc.date.accessioned2009-05-27T07:06:53Z
dc.date.available1989-12-01en_US
dc.date.available2009-05-27T07:06:53Z
dc.date.issued1989-12-01en_US
dc.description.abstractBronchoalveolar lavage using flexible fibreoptic bronchoscope was carried out in 50 patients 1-2 1/2 yr after exposure to the 'toxic gas' at Bhopal. Thirty six patients in the analysis were categorised into 3 groups (viz., mild, moderate and severe), depending upon the severity of exposure. There was an increase in cellularity in the lower respiratory tract (alveolitis) of the severely exposed patients (in both smokers and non-smokers), compared to normals (P less than 0.05). The increase in cellularity in severely exposed non-smokers was due to abnormal accumulation of macrophages (P less than 0.01), and in severely exposed smokers, to macrophages (P less than 0.01) and neutrophils (P less than 0.05). Mild and moderately exposed patients did not show significant change in cellularity in lower respiratory tract, compared to normal individuals (P greater than 0.2). There was a trend towards increasing cellularity, as the severity increased (P less than 0.0001) and higher numbers of total cells were seen in severely exposed smokers, suggesting that smoking is a risk factor. It appears, therefore, that subjects severely exposed to the toxic gas at Bhopal may have a subclinical alveolitis characterised by accumulation and possibly activation of macrophages in the lower respiratory tract. Smokers, who were exposed to the gas had in addition, accumulation of neutrophils.en_US
dc.identifier.citationVijayan VK, Pandey VP, Sankaran K, Mehrotra Y, Darbari BS, Misra NP. Bronchoalveolar lavage study in victims of toxic gas leak at Bhopal. Indian Journal of Medical Research. 1989 Dec; 90(): 407-14en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/19359
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAccidents, Occupationalen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBronchoalveolar Lavage Fluid --cytologyen_US
dc.subject.meshCyanates --poisoningen_US
dc.subject.meshDisastersen_US
dc.subject.meshEnvironmental Exposureen_US
dc.subject.meshGas Poisoning --complicationsen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshIsocyanatesen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPulmonary Fibrosis --diagnosisen_US
dc.subject.meshSmoking --adverse effectsen_US
dc.titleBronchoalveolar lavage study in victims of toxic gas leak at Bhopal.en_US
dc.typeJournal Articleen_US
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