Community prevalence of hepatitis B infection and modes of transmission in Tamil Nadu, India.

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dc.contributor.authorKurien, Ten_US
dc.contributor.authorThyagarajan, S Pen_US
dc.contributor.authorJeyaseelan, Len_US
dc.contributor.authorPeedicayil, Aen_US
dc.contributor.authorRajendran, Pen_US
dc.contributor.authorSivaram, Sen_US
dc.contributor.authorHansdak, S Gen_US
dc.contributor.authorRenu, Gen_US
dc.contributor.authorKrishnamurthy, Pen_US
dc.contributor.authorSudhakar, Ken_US
dc.contributor.authorVarghese, J Cen_US
dc.contributor.author,en_US
dc.date.accessioned2005-05-07en_US
dc.date.accessioned2009-05-27T06:32:48Z
dc.date.available2005-05-07en_US
dc.date.available2009-05-27T06:32:48Z
dc.date.issued2005-05-07en_US
dc.description.abstractBACKGROUND AND OBJECTIVE: There have been very few community based studies on prevalence of hepatitis B virus (HBV) infection in India. We undertook this study to determine the prevalence of HBV infection in a southern State of India, Tamil Nadu and to describe the important factors related to transmission of the virus in the community. METHODS: Analysis of stored blood samples from a representative population of Tamil Nadu from an earlier community cluster survey on sexually transmitted diseases (STD) prevalence using proportionate to population size (PPS) technique was done. Serum markers of HBV viz., hapatitis B surface antigen (HBsAg), hepatitis B e antigen (HBe Ag) and antibody to surface antigen (anti-HBs) were performed. RESULTS: 1981 subjects were screened in the study. HBsAg prevalence was 5.7 per cent (CI 4.6- 6.8) with 23.5 per cent (25/106) of these having positive HBe-antigen. Community seroprevalence (HbsAg + anti-HBs) of hepatitis B infection was 27.4 per cent (CI: 25.3-29.5) with the highest prevalence of 32.7 per cent (CI: 30.2-35.2) noted in the 15-20 yr age group. Significant independent association (OR 1.4; P=0.006) was detected with family history of exposure to HBV infection by logistic modeling. Other risk factors noted to have significant association were use of disposable needles during injection (OR 0.5; P=0.02) in men, smoking (OR 3; P=0.04) and use of condom (OR 0.6; P=0.08) in women. INTERPRETATION AND CONCLUSION: This community based study shows a high prevalence of hepatitis B infection in the state of Tamil Nadu with the highest prevalence being in the younger (15-20 yr) age group. High prevalence rate in childhood with e-antigenemia seen in 23.5 per cent of HBsAg positive subjects suggest childhood transmission. Poor injection practices and high-risk sexual behavior were found to be additional risk factors for transmission of the disease in the community.en_US
dc.description.affiliationChristian Medical College and Hospital, Vellore, India. kurien123@hotmail.comen_US
dc.identifier.citationKurien T, Thyagarajan SP, Jeyaseelan L, Peedicayil A, Rajendran P, Sivaram S, Hansdak SG, Renu G, Krishnamurthy P, Sudhakar K, Varghese JC, . Community prevalence of hepatitis B infection and modes of transmission in Tamil Nadu, India. Indian Journal of Medical Research. 2005 May; 121(5): 670-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/16769
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis B --epidemiologyen_US
dc.subject.meshHepatitis B Antibodies --blooden_US
dc.subject.meshHepatitis B Surface Antigens --blooden_US
dc.subject.meshHepatitis B e Antigens --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRisk Factorsen_US
dc.titleCommunity prevalence of hepatitis B infection and modes of transmission in Tamil Nadu, India.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeResearch Support, U.S. Gov't, Non-P.H.S.en_US
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