Bacteriological Aspect of Bile in Cholecystectomy Patients

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dc.contributor.authorSunkaria, Babu Lalen_US
dc.contributor.authorJamwal, Puniten_US
dc.contributor.authorMalhotra, Sitaen_US
dc.contributor.authorSharma, Sanjeeven_US
dc.contributor.authorAnant, Sarabjot Singhen_US
dc.contributor.authorThomas, Chithraen_US
dc.contributor.authorNeki, N. S.en_US
dc.date.accessioned2020-01-02T06:07:40Z
dc.date.available2020-01-02T06:07:40Z
dc.date.issued2019-03
dc.description.abstractCholecystectomy is currently a frequent performed operation. The presence of gallstones within either the gallbladder or biliary tree is associated with the bacterial colonization of the bile. Acute cholangitis spans a continuous clinical spectrum and can progress from a local biliary infection to advanced disease with sepsis and multiple organ dysfunction syndrome. Therefore, it is important to know the microbiological flora of the gallbladder before prophylactic antibiotics are given. Aim and objectives: 1.To evaluate the bacteriological profile of bile in patients undergoing cholecystectomy. 2. To determine the appropriate antibiotics for prophylaxis in cholecystectomy patients based on the bacteriological profile of bile in our study. Methods: The study was a prospective study carried out in Guru Nanak Dev Hospital, Amritsar. A total of 100 patients undergone cholecystectomy who met the inclusion criteria were included in the study. Bile was aspirated from all patients, this collected bile from gallbladder was transported to the Microbiology Department in 5cc sterile syringe. The specimen was evaluated to find out whether it is sterile or has any bacteria present. Sensitivity of isolated organisms was done against antibiotics. Results: 25 patients showed positive bile culture (25%), whereas bile was sterile in 75 patients (75%). E.Coli was the most common isolated bacteria (60%) followed by Enterococcus (20%), Staph Aureus (8%), Salmonella (8%) and Pseudomonas (4%). Postoperative wound infection was more common (20%) in group of patients with isolated organisms from bile. Conclusion: 25% of bile samples were culture positive. E coli was the most common aerobic bacteria to be isolated from the bile culture . E. coli, salmonella and pseudomonas were most sensitive to piperacillin + tazobactum and imipenum (100%). E. coli also showed sensitivity to amikacin and gentamicin (73.33% each). Enterococcus was most sensitive to linezolid and ampicillin + salbactum (100%) followed by gentamicin and amoxicillin + clavulanate (80% each). Staphylococcus was most sensitive to linezolid (100%). Antimicrobial susceptibility of potential causative organisms and the local susceptibility pattern must be taken into consideration when prescribing drugs to patients with biliary disease.en_US
dc.identifier.affiliationsAssociate Professor, Department of Surgery, GMC, Amritsar.en_US
dc.identifier.affiliationsJunior Resident, Department of Surgery, GMC, Amritsar.en_US
dc.identifier.affiliationsAssociate professor, Department of Microbiology, GMC, Amritsar.en_US
dc.identifier.affiliationsProfessor and Head, Department of Surgery, GMC, Amritsar.en_US
dc.identifier.affiliationsProfessor of Medicine, Govt. Medical College, Amritsar.en_US
dc.identifier.citationSunkaria Babu Lal, Jamwal Punit, Malhotra Sita, Sharma Sanjeev, Anant Sarabjot Singh, Thomas Chithra, Neki N. S.. Bacteriological Aspect of Bile in Cholecystectomy Patients. Annals of International medical and Dental Research. 2019 Mar; 5(2): 16-20en_US
dc.identifier.issn2395-2822
dc.identifier.issn2395-2814
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/188812
dc.languageenen_US
dc.publisherSociety for Health Care & Research Developmenten_US
dc.relation.issuenumber2en_US
dc.relation.volume5en_US
dc.source.urihttps://doi.org/10.21276/aimdr.2019.5.2.SG6en_US
dc.subjectCholelithiasisen_US
dc.subjectCholecystectomyen_US
dc.subjectBile culture and Sensitivityen_US
dc.titleBacteriological Aspect of Bile in Cholecystectomy Patientsen_US
dc.typeJournal Articleen_US
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