Diabetes induced internal organs inflammation in non-obese type 2 diabetic rats

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dc.contributor.authorMongkolpathumrat, Podsaweeen_US
dc.contributor.authorNokkaew, Nuttikarnen_US
dc.contributor.authorAdulyaritthikul, Punyanuchen_US
dc.contributor.authorKongpol, Kantapichen_US
dc.contributor.authorSanit, Jantiraen_US
dc.contributor.authorPanyupa, Pankhongen_US
dc.contributor.authorKumphune, Sarawuten_US
dc.date.accessioned2020-10-16T08:55:55Z
dc.date.available2020-10-16T08:55:55Z
dc.date.issued2019-03
dc.description.abstractDiabetic complications may in part be due to inflammation. Diabetes can also develop in non-obese people.Nonetheless, organ inflammation in non-obese type 2 diabetes mellitus animals has never been investigated. The GotoKakizaki rats were divided into two groups: diabetes and diabetes treated with metformin. The glycemia parameterswere then determined. Serum and internal organs, including the liver, kidney, and brain were collected to determinethe levels of inflammatory cytokine and mRNA expression. The research found an increase in interleukin-6 (IL-6)and IL-1β cytokine levels in the liver of the diabetic group, which corresponds with the mRNA expression of bothcytokines. The metformin group significantly reduces the mRNA expression of liver IL-6. In the kidney, there was anincrease in IL-6 cytokine levels in the diabetic group, while the metformin group could reduce the mRNA expressionlevel of tumor necrosis factor α (TNF-α). In addition, there were IL-6 and TNF-α cytokines level increased in thebrain of the diabetic group. IL-1β mRNA expression levels increased in the diabetic group and were reduced by themetformin treatment. The metformin treatment reduced serum TNF-α cytokines. In summary, this study demonstratedthat internal organ inflammation in non-obese diabetic rats, which could provide evidence for organ inflammation,may potentially explain diabetic complications.en_US
dc.identifier.affiliationsBiomedical Research Unit in Cardiovascular Sciences, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailanden_US
dc.identifier.affiliationsGraduate program in Biomedical Sciences, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand.en_US
dc.identifier.affiliationsBiomedical Research Unit in Cardiovascular Sciences, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailanden_US
dc.identifier.affiliationsGraduate program in Biomedical Sciences, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand.en_US
dc.identifier.affiliationsBiomedical Research Unit in Cardiovascular Sciences, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailanden_US
dc.identifier.affiliationsGraduate program in Biomedical Sciences, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand.en_US
dc.identifier.affiliationsBiomedical Research Unit in Cardiovascular Sciences, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailanden_US
dc.identifier.affiliationsGraduate program in Biomedical Sciences, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand.en_US
dc.identifier.affiliationsDepartment of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand.en_US
dc.identifier.citationMongkolpathumrat Podsawee, Nokkaew Nuttikarn, Adulyaritthikul Punyanuch, Kongpol Kantapich, Sanit Jantira, Panyupa Pankhong, Kumphune Sarawut. Diabetes induced internal organs inflammation in non-obese type 2 diabetic rats. Journal of Applied Pharmaceutical Science. 2019 Mar; 2019 Mar: 041-049en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210542
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber3en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2019.90307en_US
dc.subjectDiabetesen_US
dc.subjectinternal organsen_US
dc.subjectcomplicationsen_US
dc.subjectinflammationen_US
dc.subjectmetforminen_US
dc.subjectGoto-Kakizaki rat.en_US
dc.titleDiabetes induced internal organs inflammation in non-obese type 2 diabetic ratsen_US
dc.typeJournal Articleen_US
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