Quantitation of isotype specific Haemophilus influenzae antibody in serum and saliva of normal subjects and chronic bronchitics.

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dc.contributor.authorCripps, A Wen_US
dc.contributor.authorClancy, R Len_US
dc.contributor.authorMurree-Allen, Ken_US
dc.contributor.authorEngel, M Ben_US
dc.contributor.authorPang, Gen_US
dc.contributor.authorYeung, Sen_US
dc.date.accessioned2009-05-27T17:07:40Z
dc.date.available2009-05-27T17:07:40Z
dc.date.issued1986-06-01en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractAn immunoglobulin isotype specific radioimmunoassay procedure has been developed to assess the antibody response to Haemophilus influenzae somatic antigens in serum and mucosal secretions. This assay was reproducible (between assay CV% 13.9; within assay CV% 4.5 IgG, 3.9 IgA, 3.0 IgM) and specific for H1/H2 antigens. Different patterns of antibody were observed in healthy children (aged 5-10 years), adults and patients with chronic bronchitis. In serum, 20% of chronic bronchitics had antibody levels greater than those observed in healthy adults. In saliva, the proportion of chronic bronchitic patients with high levels (greater than 12% binding) of IgG specific antibody was significantly greater (P less than 0.05) than in healthy adults or children. The proportion of children and chronic bronchitics which had antibody levels of up to 4% binding was significantly greater (P less than 0.05) than that observed in healthy adults. A similar pattern was observed for IgM specific antibody. The occurrence of IgA specific antibody in the saliva in children and chronic bronchitics was consistently greater than that observed in adults for all levels of antibody (P less than 0.05). Chronic bronchitics with high levels of antibody had greater infection and mortality rates.en_US
dc.identifier.citationCripps AW, Clancy RL, Murree-Allen K, Engel MB, Pang G, Yeung S. Quantitation of isotype specific Haemophilus influenzae antibody in serum and saliva of normal subjects and chronic bronchitics. Asian Pacific Journal of Allergy and Immunology. 1986 Jun; 4(1): 5-11en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36510
dc.language.isoengen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntibodies, Bacterial --analysisen_US
dc.subject.meshAntigens, Bacterial --isolation & purificationen_US
dc.subject.meshBronchitis --immunologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshHaemophilus influenzae --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin A --analysisen_US
dc.subject.meshImmunoglobulin Allotypes --analysisen_US
dc.subject.meshImmunoglobulin G --analysisen_US
dc.subject.meshImmunoglobulin M --analysisen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRadioimmunoassayen_US
dc.subject.meshSaliva --immunologyen_US
dc.titleQuantitation of isotype specific Haemophilus influenzae antibody in serum and saliva of normal subjects and chronic bronchitics.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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