Nephro protection property of double blockade versus single blocked of RAAS in delaying the progression of CKD

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dc.contributor.authorGupta, Arvinden_US
dc.contributor.authorNarain, Upmaen_US
dc.contributor.authorDabu, Romaren_US
dc.date.accessioned2020-04-09T07:40:06Z
dc.date.available2020-04-09T07:40:06Z
dc.date.issued2018-05
dc.description.abstractBackground: Dual renin angiotensin aldosterone system blockade using angiotensin receptor blockers in combination with angiotensin converting enzyme inhibitors is reported to improve proteinuria in non-diabetic patients.Methods: A prospective observational study was done on 810 non-diabetic chronic kidney disease patients during July 2012 to August 2014 to compare the nephro protection property of double blockade and single blocked of renin angiotensin aldosterone system in delaying the progression of chronic kidney disease.Results: At the end of 24 months urinary protein excretion rate of group I and group III were compared by using student t-test and p value (0.0001) was found significant. Similarly, on comparing group II and group III, p value (0.003) was again significant. Mean arterial blood pressure of group I and group III were statistically significant (<0.0496) while comparing group II and group III, p value (0.0419) was again significant.Conclusions: The study concludes that the use of double renin angiotensin aldosterone system blockade therapy is more effective than monotherapy at reducing albuminuria and proteinuiria, and in decreasing blood pressure at the same time not causing significant deterioration in glomerular filtration rate. Newer potassium lowering therapies can effectively and safely correct hyperkalemia and maintain normokalemia in patients receiving background treatment with renin angiotensin aldosterone system blockade. However, the use of new potassium binders for cardiovascular and renal risk reduction with combined renin angiotensin aldosterone system blockade therapy will require phase III trials.en_US
dc.identifier.affiliationsDepartment of Medicine, Motilal Nehru Medical College, Allahabad, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Microbiology, Tejas Microdiagnostic, Allahabad, Uttar Pradesh, Indiaen_US
dc.identifier.citationGupta Arvind, Narain Upma, Dabu Romar. Nephro protection property of double blockade versus single blocked of RAAS in delaying the progression of CKD. International Journal of Advances in Medicine. 2018 May; 5(3): 748-753en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/194013
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume5en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20182135en_US
dc.subjectCKDen_US
dc.subjectDouble blockadeen_US
dc.subjectHyperkalemiaen_US
dc.subjectNon-diabeticen_US
dc.subjectRAASen_US
dc.subjectSingle blockadeen_US
dc.titleNephro protection property of double blockade versus single blocked of RAAS in delaying the progression of CKDen_US
dc.typeJournal Articleen_US
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