Combination of anticholinergic agent and H2 receptor antagonist in duodenal ulcer treatment--a randomized, double blind multicenter study.

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dc.contributor.authorAgrawal, B Ken_US
dc.contributor.authorSuman, Aen_US
dc.contributor.authorKumar, Aen_US
dc.contributor.authorBroor, S Len_US
dc.contributor.authorRajasambandam, Pen_US
dc.contributor.authorPalaniswamy, K Ren_US
dc.contributor.authorMohan, A Ten_US
dc.contributor.authorGupta, J Pen_US
dc.date.accessioned1993-07-01en_US
dc.date.accessioned2009-05-29T02:09:35Z
dc.date.available1993-07-01en_US
dc.date.available2009-05-29T02:09:35Z
dc.date.issued1993-07-01en_US
dc.description.abstractBACKGROUND: The acid suppressive abilities of H2 receptor antagonists and anticholinergics have been claimed to be additive. METHODS: A multicenter, double-blind, randomized trial comparing ranitidine (150 mg) plus propantheline bromide 15 mg at bedtime to ranitidine 300 mg alone at bedtime was conducted in 161 patients with endoscopically confirmed uncomplicated duodenal ulcer. RESULTS: After six weeks of therapy, ulcer healing rates in the two groups were comparable ie 80% in the combination group (ranitidine + propantheline) and 79.4% in the ranitidine group. Pain relief after one, two and four weeks of treatment was also comparable in the two groups. Side effects to drugs were minor and comparable in both the groups. CONCLUSION: A combination of 150 mg ranitidine and 15 mg propantheline bromide is as efficacious as 300 mg ranitidine in inducing healing of uncomplicated duodenal ulcers, with similar side-effects but at greatly reduced cost.en_US
dc.description.affiliationIndira Gandhi Institute of Medical Sciences, Patna.en_US
dc.identifier.citationAgrawal BK, Suman A, Kumar A, Broor SL, Rajasambandam P, Palaniswamy KR, Mohan AT, Gupta JP. Combination of anticholinergic agent and H2 receptor antagonist in duodenal ulcer treatment--a randomized, double blind multicenter study. Indian Journal of Gastroenterology. 1993 Jul; 12(3): 89-91en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/63806
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshDuodenal Ulcer --drug therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPropantheline --administration & dosageen_US
dc.subject.meshRanitidine --administration & dosageen_US
dc.subject.meshTime Factorsen_US
dc.titleCombination of anticholinergic agent and H2 receptor antagonist in duodenal ulcer treatment--a randomized, double blind multicenter study.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeMulticenter Studyen_US
dc.typeRandomized Controlled Trialen_US
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