Effect of garlic (allium sativum) on hematology and erythrocyte antioxidant defense system of albino rats exposed to heavy metals (nickel II & chromium VI).

Simple item page
dc.contributor.authorTikare, Swati N
dc.contributor.authorYendigeri, Saeed
dc.contributor.authorGupta, Amrita Das
dc.contributor.authorDhundasi, Salim A
dc.contributor.authorDas, Kusal K
dc.date.accessioned2013-04-12T10:40:54Z
dc.date.available2013-04-12T10:40:54Z
dc.date.issued2012-04
dc.description.abstractHeavy metals are stable environmental contaminants, causing various alterations in target tissues. Garlic has some beneficial effect in preventing heavy metal induced various alteration. The objective was to investigate the possible protective role of fresh aqueous homogenate of garlic on hematology, erythrocyte antioxidant defense system in male albino rats treated with NiSO4 and K2Cr2O7. Rats were divided into six groups. Group I was untreated control. Group II was given aqueous homogenate of garlic (orally). Group III was administered with nickel sulfate (i.p). Group IV was given NiSO4 and garlic simultaneously. Group V was administered with K2Cr2O7 (i.p). Group VI were treated simultaneously with K2Cr2O7 and garlic. RBC, WBC, platelet count, PCV%, hemoglobin concentration decreased significantly and clotting time increased significantly after nickel treatment. After chromium treatment all the values decreased except clotting time. Increased malondialdehyde and glutathione level after nickel and chromium treatment was observed. Also erythrocyte superoxide dismutase, glutathione peroxidase and catalase activities significantly increased after nickel and chromium treatment. Simultaneous garlic supplementation exhibited protective role to combat nickel toxicity, whereas no such beneficial effects were observed for chromium (VI). Garlic may partially prevent nickel and chromium induced alteration but such ameliorated effects as an antioxidant is only restricted on nickel induced alteration.en_US
dc.identifier.citationTikare Swati N, Yendigeri Saeed, Gupta Amrita Das, Dhundasi Salim A, Das Kusal K. Effect of garlic (allium sativum) on hematology and erythrocyte antioxidant defense system of albino rats exposed to heavy metals (nickel II & chromium VI). Indian Journal of Physiology and Pharmacology. 2012 Apr-Jun; 56(2): 137-146.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/146103
dc.language.isoenen_US
dc.source.urihttps://www.ijpp.com/IJPP%20archives/2012_56_2_%20Apr%20-%20Jun/137-146.pdfen_US
dc.subjectallium sativumen_US
dc.subjectnickel IIen_US
dc.subjectchromium VIen_US
dc.subjecthematologyen_US
dc.subjecterythrocyte antioxidant defenseen_US
dc.titleEffect of garlic (allium sativum) on hematology and erythrocyte antioxidant defense system of albino rats exposed to heavy metals (nickel II & chromium VI).en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijpp2012v56n2p137.pdf
Size:
593.61 KB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Physiology and Pharmacology